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5 Written questions

5 Matching questions

  1. isocitrate
  2. NAD+
  3. step 3
  4. step 4
  5. what kinds of things inhibit the enzymes at the control points?
  1. a a 2-electron oxidizing agent that is reduced to NADH; comes from nicatinamide, or niacin
  2. b ATP, NADH, succinyl CoA
  3. c alpha-ketoglutarate (5c) is oxidized to form succinyl coA (4c) with the help of alpha-ketoglurate dehydrogenase complex, transforming NAD+ into NADH, bringing in CoA, and releasing CO2 and H+
  4. d isocitrate (6c) is oxidized to form alpha-ketoglutarate (5c) with the help of isocitrate dehydrogenase, transforming NAD+ into NADH and releasing H+ and CO2
  5. e a secondary alcohol that is oxidized to a ketone (alpha-kg)

5 Multiple choice questions

  1. succinyl CoA (4c) is transformed into succinate (4c) with the help of succinyl CoA synthetase, transforming GDP + Pi into GTP with the energy released from the C-S bond
  2. fumarate (4c) is transformed into malate (4c) with the help of fumarase, bringing in 1 molecule of H2O
  3. pyruvate, fats, amino acids, ketone bodies
  4. the conjugate base of citric acid; a tertiary ROH that is not easily oxidized (that's why it's isomerized in the cycle)
  5. no reversal needed, no quick mechanism for NAD+ regeneration (too oxidative), more acetyl-CoA available

5 True/False questions

  1. NAD+ vs. NAD: which is the better oxidizing agent? reducing agent?FAD, NAD+

          

  2. what can Acetyl-CoA be turned into?fats, ketone bodies, cholesterol (NOT glucose!)

          

  3. step 2oxaloacetate (4c) is condensed with an acetyl group (2c) to form citrate (6c) with the help of citrate synthase

          

  4. what do you need to know about pyruvate dehydrogenase complex?its coenzymes include b-vitamins (water soluble) that act as recyclable prosthetic groups; it's the most irreversible reaction in our body/there's no getting around it, so once acetyl-CoA is made, you cannot go back

          

  5. pyruvate to acetyl-coathe conjugate base of citric acid; a tertiary ROH that is not easily oxidized (that's why it's isomerized in the cycle)