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5 Written questions

5 Matching questions

  1. step 2
  2. step 7
  3. pyruvate to acetyl-coa
  4. step 8
  5. what is citrate?
  1. a the conjugate base of citric acid; a tertiary ROH that is not easily oxidized (that's why it's isomerized in the cycle)
  2. b pyruvate + NAD+ + CoA-SH (coenzyme A) ----pyruvate dehydrogenase complex---> CH3C(=O)SCoA (acetyl coa) + NADH + CO2
  3. c citrate (6c) is isomerized to isocitrate (6c) with the help of aconitase
  4. d malate (4c) is oxidized into oxaloacetate with the help of malate dehydrogenase, transforming NAD+ into NADH and releasing H+
  5. e fumarate (4c) is transformed into malate (4c) with the help of fumarase, bringing in 1 molecule of H2O

5 Multiple choice questions

  1. its coenzymes include b-vitamins (water soluble) that act as recyclable prosthetic groups; it's the most irreversible reaction in our body/there's no getting around it, so once acetyl-CoA is made, you cannot go back
  2. flavin adenine dinucleotide, a biological oxidizing agent that is reduced to FADH2; comes from riboflavin
  3. succinyl CoA (4c) is transformed into succinate (4c) with the help of succinyl CoA synthetase, transforming GDP + Pi into GTP with the energy released from the C-S bond
  4. oxaloacetate (4c) is condensed with an acetyl group (2c) to form citrate (6c) with the help of citrate synthase
  5. a 2-electron oxidizing agent that is reduced to NADH; comes from nicatinamide, or niacin

5 True/False questions

  1. to break down 1 glucose molecule you need ___ NAD+ from inside & ____ NAD+ from outside mitochondria, ___ oxaloacetate, _____ ADP, and ____ of each enzyme8 (2 from pyruvate to acetyl coa, 6 from krebs), 2 (glycolysis), 1, 4, 1


  2. step 6succinate (4c) is oxidized into fumarate (4c) with the help of succinate dehydrogenase, transforming FAD into FADH2


  3. NAD+ vs. NAD: which is the better oxidizing agent? reducing agent?FAD, NAD+


  4. isocitratea secondary alcohol that is oxidized to a ketone (alpha-kg)


  5. which intermediates of the krebs cycle can be made into glucose?all of them