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5 Written questions

5 Matching questions

  1. what is citrate?
  2. isocitrate
  3. step 1
  4. NAD+
  5. how krebs differs from glycolysis
  1. a a 2-electron oxidizing agent that is reduced to NADH; comes from nicatinamide, or niacin
  2. b the conjugate base of citric acid; a tertiary ROH that is not easily oxidized (that's why it's isomerized in the cycle)
  3. c a secondary alcohol that is oxidized to a ketone (alpha-kg)
  4. d no reversal needed, no quick mechanism for NAD+ regeneration (too oxidative), more acetyl-CoA available
  5. e oxaloacetate (4c) is condensed with an acetyl group (2c) to form citrate (6c) with the help of citrate synthase

5 Multiple choice questions

  1. fumarate (4c) is transformed into malate (4c) with the help of fumarase, bringing in 1 molecule of H2O
  2. its coenzymes include b-vitamins (water soluble) that act as recyclable prosthetic groups; it's the most irreversible reaction in our body/there's no getting around it, so once acetyl-CoA is made, you cannot go back
  3. malate (4c) is oxidized into oxaloacetate with the help of malate dehydrogenase, transforming NAD+ into NADH and releasing H+
  4. isocitrate (6c) is oxidized to form alpha-ketoglutarate (5c) with the help of isocitrate dehydrogenase, transforming NAD+ into NADH and releasing H+ and CO2
  5. citrate (6c) is isomerized to isocitrate (6c) with the help of aconitase

5 True/False questions

  1. to break down 1 glucose molecule you need ___ NAD+ from inside & ____ NAD+ from outside mitochondria, ___ oxaloacetate, _____ ADP, and ____ of each enzyme8 (2 from pyruvate to acetyl coa, 6 from krebs), 2 (glycolysis), 1, 4, 1


  2. what can Acetyl-CoA be turned into?fats, ketone bodies, cholesterol (NOT glucose!)


  3. which intermediates of the krebs cycle can be made into glucose?fats, ketone bodies, cholesterol (NOT glucose!)


  4. there are ___ control pointsinner mitochondrial matrix


  5. what can be turned into Acetyl-CoA?pyruvate, fats, amino acids, ketone bodies