Infectious disease 3

Plague (Y. pestis), presenting as acute lymphadenopathy in its

Click the card to flip 👆

1 / 13

Terms in this set (13)

Plague (Y. pestis), presenting as acute lymphadenopathy in its

Transmission mechanisms: Yersinia pestis -has a bridging vector between

rodents (primary reservoir) and humans (secondary reservoir)

Lymphadenopathy -

inflammation of a lymph node

Y. pestis is a disseminating disease which

moves around and can become established in lymph nodes

Y. pestis greatly affected human history largely apocalyptic it spread from the east. 3 plague pandemics with y. pestis

500AD (25 million deaths), 14th century black death (bubonic presentation necrotic legions causing blackening of the epidermis- 200 to 500 million deaths). Modern plague into 19th century lasted for decade ended around the civil war.

Alexandre Yersin French physician, Pasteur Institute—discovered the

causative agent of plague during the Modern pandemic as Pasteurella pestis—later named Yersinia

Y. pestis is primarily a

rat pathogen and maintains its primary reservoir in rats and other rodents

Y. pestis can be indirectly transmitted to humans by the

bite of the rat flea (parenteral)

in Y. pestis Bubonic form - direct host to host transmission

Y. pestis in the bubonic form follows indirect (parenteral) ,and only is transferred

incidentally to humans via the flea bite