Infectious Disease 5

Both Salmonella and Shigella are
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Terms in this set (19)
Like Salmonella, Shigella invades through the intestine—then replicates inadjacent intestinal cells by lateral propagationShigella replicates in cytoplasm, and invades adjacent cells by lateral propagation—this is achieved bypolar condensation of actin3 most common mechanisms for toxin damage areImmunopathological, cell death/cell damage, and pharmacological damageThree important toxins include :Shiga toxin, E. coli LT-I, Pertussis toxinMembrane-damaging (ex. Pore-forming toxins, PFTs) haveBroad target range and toxicity and usually are CytotoxicIntracellular-acting(ex. AB toxins) work bySpecific effect and cellular targets, Receptor mediated uptake internalization or translocation, Hit intracellular target(s) and may or may not be cytotoxicPFT A large group of toxins that formpores in the membranes of bacteria, plants and mammals and cause membrane permeability and ion imbalanceAB organization of toxinsThe A domain (aka effector) is commonly an enzyme or a factor that directly interacts with a host protein(s) andThe B domain comprises thereceptor-binding function which provides tropism to specific cell types