2 Written questions
2 Multiple choice questions
- Competitively inhibits D-alanine ligase enzyme so cannot syntheses from L to D-alanine
Don't have crosslinking if not have D-alanine at the end
- Interferes with dephosphorylation of isoprenyl pyrophosphate; molecule carries peptidoglycan building blocks
2 True/False questions
Beta-Lactam Antibiotics → Prevents cross-linking of peptides and synthesis of peptide strnd through autolysin activators. Does not allow enzyme to cross link peptide strands.
Methicillin, Oxacillin, Nafcillin, Cloxacillin, Dicloxacillin
Vancomyocin → Inhibits linkages of peptidoglycan constituents.
Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall)
Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides
Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix