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2 Written questions

2 Multiple choice questions

  1. Competitively inhibits D-alanine ligase enzyme so cannot syntheses from L to D-alanine

    Don't have crosslinking if not have D-alanine at the end
  2. Interferes with dephosphorylation of isoprenyl pyrophosphate; molecule carries peptidoglycan building blocks

2 True/False questions

  1. Beta-Lactam AntibioticsPrevents cross-linking of peptides and synthesis of peptide strnd through autolysin activators. Does not allow enzyme to cross link peptide strands.

    Methicillin, Oxacillin, Nafcillin, Cloxacillin, Dicloxacillin

          

  2. VancomyocinInhibits linkages of peptidoglycan constituents.

    Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall)

    Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

    Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix