2 Written questions
2 Multiple choice questions
- Competitively inhibits D-alanine ligase enzyme so cannot syntheses from L to D-alanine
Don't have crosslinking if not have D-alanine at the end
- Interferes with dephosphorylation of isoprenyl pyrophosphate; molecule carries peptidoglycan building blocks
2 True/False questions
Cephalosporins → Come from the fungus CephalosporiumAcremonium.
Work by the same mechanisms as penicillin's; but work on gram (+), not effective against gram (-)
Have beta-lactam ring with dihydrothiazine ring, makes more resistant to beta-lactamases
Beta-Lactam Antibiotics → Prevents cross-linking of peptides and synthesis of peptide strnd through autolysin activators. Does not allow enzyme to cross link peptide strands.
Methicillin, Oxacillin, Nafcillin, Cloxacillin, Dicloxacillin