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2 Written questions

2 Multiple choice questions

  1. Ampicillin and Amoxicillin
    o Broad-spectrum penicillin's; safe for prescription but not resistant to beta-lactamase
    o Effective aginst gram (-)

    Extended-spectrum penicillin's *not know
    o Works against most bacteria, gram(-) and gram (+)

    Carbenicillin, Ticaracillin, Azlocillin, Piperacillin.
    - May have hypersensitive reaction (rashes, fever) that may lead to anaphylactic shock in some cases
    - Can cause antiplatelet effects
  2. Inhibits linkages of peptidoglycan constituents.

    Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall)

    Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

    Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix

2 True/False questions

  1. BacitracinInterferes with dephosphorylation of isoprenyl pyrophosphate; molecule carries peptidoglycan building blocks


  2. CephalosporinsCompetitively inhibits D-alanine ligase enzyme so cannot syntheses from L to D-alanine

    Don't have crosslinking if not have D-alanine at the end