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2 Written questions

2 Multiple choice questions

  1. Ampicillin and Amoxicillin
    o Broad-spectrum penicillin's; safe for prescription but not resistant to beta-lactamase
    o Effective aginst gram (-)

    Extended-spectrum penicillin's *not know
    o Works against most bacteria, gram(-) and gram (+)

    Carbenicillin, Ticaracillin, Azlocillin, Piperacillin.
    - May have hypersensitive reaction (rashes, fever) that may lead to anaphylactic shock in some cases
    - Can cause antiplatelet effects
  2. Come from the fungus CephalosporiumAcremonium.

    Work by the same mechanisms as penicillin's; but work on gram (+), not effective against gram (-)

    Have beta-lactam ring with dihydrothiazine ring, makes more resistant to beta-lactamases

2 True/False questions

  1. Beta-Lactam AntibioticsPrevents cross-linking of peptides and synthesis of peptide strnd through autolysin activators. Does not allow enzyme to cross link peptide strands.

    Methicillin, Oxacillin, Nafcillin, Cloxacillin, Dicloxacillin

          

  2. VancomyocinInhibits linkages of peptidoglycan constituents.

    Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall)

    Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

    Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix