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2 Written questions

2 Multiple choice questions

  1. Prevents cross-linking of peptides and synthesis of peptide strnd through autolysin activators. Does not allow enzyme to cross link peptide strands.

    Methicillin, Oxacillin, Nafcillin, Cloxacillin, Dicloxacillin
  2. Inhibits linkages of peptidoglycan constituents.

    Prevents incorporation of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptide subunits into the peptidoglycan matrix (structural compenent of gram + cell wall)

    Large hydrophobic molecule that forms hydrogen bonds with terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

    Binding to D-Ala-D-Ala prevents incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix

2 True/False questions

  1. BacitracinInterferes with dephosphorylation of isoprenyl pyrophosphate; molecule carries peptidoglycan building blocks


  2. PenicillinAmpicillin and Amoxicillin
    o Broad-spectrum penicillin's; safe for prescription but not resistant to beta-lactamase
    o Effective aginst gram (-)

    Extended-spectrum penicillin's *not know
    o Works against most bacteria, gram(-) and gram (+)

    Carbenicillin, Ticaracillin, Azlocillin, Piperacillin.
    - May have hypersensitive reaction (rashes, fever) that may lead to anaphylactic shock in some cases
    - Can cause antiplatelet effects