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BIO 315: Lecture Exam 4
Terms in this set (40)
Regulation of ferritin to help detoxify the presence of intracellular iron is an example of:
To mark protein that will be degraded through the proteasome, what modification occurs to the protein?
Ubiquitination of lysine residues
Which of the following statements concerning the lac operon is NOT true?
-IT'S A TYPE OF REPRESSIBLE OPERON
-Expression levels are inversely correlated to the levels of glucose
-The glucose effect is a type of positive control for the lac operon
-CRP-cAMP binding to the promoter stimulates transcription
How are most eukaryotic transcription regulators able to affect transcription when their binding sites in enhancers are far from the promoter?
By looping out the intervening DNA between their binding site and the promoter
Which of the following is NOT true concerning transcription factors (TF)?
-TF can act as transcriptional activators or repressors
-TF control gene expression, which gives rise to phenotypes within cells
-TF contain DNA-binding and activation domains
-TF generally bind to the major groove of DNA
-TF GENERALLY ACTS AS MONOMERS
An example of constitutive heterochromatic would be:
Centromeres & telomeres
Generation of different transcripts from one fibronectin gene is an example of:
An example of facultative heterochromatin would be:
The Barr body
What technique is used to determine DNA binding sites for transcription factors genome-wide?
What enzyme is responsible for the maintenance of the ends of the chromosomes?
What describes the DNA replication process in bacteria and eukaryotes?
Semiconservative & semi-discontinuous replication
What type of DNA repair utilizes proteins that scan DNA sequences, recognize base alterations and cleave the base from the sugar?
Base excision repair
During DNA replication, movement of the replication fork causes the formation of positive and supercoilings as the DNA strands are unwound. In bacteria, which of the following is responsible for inducing negative supercoiling so that DNA replication can proceed?
Bacterial DNA polymerase I exhibits what type of activity that is lacking in DNA polymerase III?
5' to 3' exonuclease activity
If the genome of the bacterium E. coli requires about 20 minutes to replicate itself, how can the genome of the fruit fly Drosophila be replicated in only 3 minutes?
Drosophila DNA contains more origins of replication than E. coli DNA
In mammalian cells, high energy sources can induce double stranded breaks in the DNA duplex to stimulate repair. Which of the following repair mechanisms generally involves the introduction of small deletions after repair is completed?
non-homologous end joining
In bacteria, post-replicative mismatch repair of incorrectly added nucleotides after DNA replication is dependent on the detection of which of the following?
Methylation of parental DNA strand
How many origins of replication are there in the bacterial genome?
In this type of replication, the two original strands would remain together (after serving as templates), as would the two newly synthesized strands.
Which bacterial DNA polymerase is the major enzyme responsible for DNA replication?
DNA polymerase III
Starting from when a cell in G0 re-enters the cell cycle, what is the correct order of progression through the cell cycle?
Which of the following acts as a ubiquitin ligase complex to cause the activation of separase?
Which mutation would cause a cell to arrest in G2 phase and not progress into mitosis?
Loss of function mutation in Cdc25
Which of the following structures/organelles remain relatively intact through mitosis?
-GC & P
-GC, P, & N
During cytokinesis, the contractile ring theory suggests that a thin band of actin and ______ filaments generate the force needed to cleave the cell.
Entry into M phase is regulated by _____ in the frog embryo and _____ in fission yeast.
MPF; cdc2 kinase/mitotic cyclins
Which cells in the human body normally do not divide but can be induced to do so?
-Hematopoietic stem cells
Which stage of mitosis is associated with all of the chromosomes being positioned equidistant between both spindle poles?
Which protein, associated with the protein scaffold, is required during early prophase for chromosomal compaction?
Topoisomerase II & condensin
Based on the results from Cdk knockout mice, which Cdk is the only one required to drive mammalian cell through the cell cycle?
During calcium-mediated calcium signaling, what re-establishes the ER stores of calcium?
Which calcium binding protein is associated with receptor-mediated endocytosis?
Which of the following molecules is not a second messenger?
ALL of the above
Which of the following proteins is an effector that generates cAMP as a second messenger?
STATs represent which type of proteins that can interact with active receptor tyrosine kinases?
During epinephrine-mediated glucose release, protein kinase A (PKA) has multiple functions in the cell. Which of the following is NOT a function of PKA?
-Activation of the transcription factor CREB
-Activation of glycogen phosphorylase
-Stimulation of glycogen breakdown
-Inactivation of glycogen synthase
-SUPPRESSION OF GLUCONEOGENESIS
The insulin receptor is an example of which class of receptor involved in cell signaling?
-G-protein coupled receptor
-RECEPTOR PROTEIN-TYROSINE KINASE
-Cytoplasmic protein-tyrosine kinase
-Steroid hormone receptor
Which of the following molecules is NOT a lipid-bound second messenger?
-Diacylglycerol & PIP3
-Discylglycerol & IP3
___ accelerate the exchange of GDP for GTP for Ras, thus keeping Ras active, whereas _____ inhibit the release of a bound GDP from Ras, thus maintaining it in the inactive, GDP-bound state.
The rhodopsin receptor is an example of which class of receptor involved in cell signaling?
G-protein coupled receptor
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