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Biochem Final Exam
Terms in this set (40)
The cofactor NAD+ is associated most closely with which of the following B vitamins?
Which one of the following statement about gluconeogenesis is correct?
it consists entirely of the reactions of glycolysis, operating in reverse direction.
During glycolysis, glucose 1-phosphate is converted to fructose 6-phosphate in two successive reactions. delta g for the overall reaction is:
the oxidation of glyceraldehyde 3-phosphate (G3P) by NAD+ involves
the transfer of H- to NAD+
the conversion of 1 mol of fructose 1,6-bisphosphate to 2 mol of pyruvate by the glycolytic pathway results in a net formation of:
2 mol of NADH and 4 mol of ATP
all of the following contribute to the large, negative, free-energy change upon hydrolysis of "high-energy" compounds except:
high activation energy of forward reaction
hydrolysis of 1 M glucose 6-phosphate catalyzed by glucose 6-phosphatase is 99% complete equilibrium. which of the following statements is most nearly correct?
delta g = -11 kj/mol
E of the NAD+/NADH half reaction is -.32 V. The E of the acetaldehyde/ethanol half reaction is -.197 V. Under standard biochemical conditions, the "spontaneous" reaction is:
acetaldehyde + NADH + H --> ethanol + NAD+
the step of glycolysis between glyceraldehyde 3-phosphate and 3-phosphoglycerate involve all of the following except:
oxidation of NADH to NAD
the overall balanced reaction for the fermentation of glucose of vertebrates is
Glucose + 2 ADP + 2Pi --> 2 lactate + 2 ATP + 2 H2O
which of the following statements is true of muscle glycogen phosphorylase?
it exists in an active (a) form and an inactive (b) form that is allosterically regulated by AMP
malonate is a competitive inhibitor of succinate dehydrogenase. if malonate is added to a mitochondrial preparation that is oxidixing pyruvate as a substrate, which of the following compounds would you expect to decrease in concentration?
which of the following is not true of the regulation of glucokinase (hexokinase IV)
it is allosterically inhibited by glucose 6 phosphate
during seed germination, the glyoxylate pathway is important to plants because it enables them to
carry out the net synthesis of glucose from acetyl coA
the regulated enzyme of the citric acid cycle are generally activated by
high concentration of NAD+
which of the following enzymes does not catalyze an anaplerotic reaction
which one of the following intermediates of the citric acid cycle is not generally considered to be a direct biosynthetic precursor
oxaloacetate uniformly labeled with 14C is condensed with unlabeled acetyl-coA. after a single pass through the citric acid cycle back to oxaloacetate, what fraction of the original radioactivity will be found in the oxaloacetate?
There is reciprocal regulation of glycolytic and gluconeogenic reactions interconverting fructose-6-phosphate and fructose-1,6-bisphosphate. Which one of the following statements about this regulation is not correct?
A) Fructose-2,6-bisphosphate activates phosphofructokinase-1.
B) Fructose-2,6-bisphosphate inhibits fructose-1,6-bisphosphatase.
C) The fructose-1,6-bisphosphatase reaction is exergonic.
D) The phosphofructokinase-1 reaction is endergonic.
E) This regulation allows control of the direction of net metabolite flow through the pathway.
the phosphofructokinase-1 reaction is endergonic
Conversion of 1 mol of acetyl-CoA to 2 mol of CO2 and CoA via the citric acid cycle results in the net production of:
A) 1 mol of citrate.
B) 1 mol of FADH2.
C) 1 mol of NADH.
D) 1 mol of oxaloacetate.
E) 7 mol of ATP.
1 mol FADH2
Fatty acids are activated to acyl-CoA and the acyl group is further transferred to carnitine because:
acyl-carnitines readily cross the mitochondrial inner membrane, but acyl-CoAs do not.
Glutamate is metabolically converted to alpha-ketoglutarate and NH4+ by a process described as:
When the delta G'o of the ATP synthesis reaction is measured on the surface of the ATP synthase enzyme, it is found to be close to zero. This is thought to be due to:
stabilization of ATP relative to ADP by enzyme binding.
Which of the following is (are) true of the oxidation of 1 mol of palmitate (a 16-carbon saturated fatty acid, 16:0) by the beta-oxidation pathway, beginning with the free fatty acid in the cytoplasm?
1) Activation of the free fatty acid requires the equivalent of two ATPs.
2) Inorganic pyrophosphate (PPi) is produced.
3) Carnitine functions as an electron acceptor.
4) 8 mole of FADH2 are formed.
5) 8 mol of acetyl-CoA are formed.
6) There is no direct involvement of NADP+.
1,2 and 5
If a person's urine contains unusually high concentrations of urea, which one of the following diets has he or she probably been eating recently?
Very low carbohydrate, very high protein
The major site of formation of acetoacetate from fatty acids is the:
Serine or alanine may enter the citric acid cycle as acetyl-CoA after conversion to:
Which of the following fatty acids could be considered to be somewhat glucogenic?
Almost all of the oxygen (O2) one consumes in breathing is converted to:
Excess ammonia produced as part of the catabolism of muscle protein is transported to the liver for processing to urea as:
Which of the following is not required in the synthesis of fatty acids?
In its role in the hormonal hierarchy, the hypothalamus produces and releases:
The biosynthesis of triacylglycerols from acetate occurs mainly in:
humans after ingestion of excess carbohydrate.
Long-term maintenance of body weight is regulated by the hormone:
Which of the following is not an intermediate in the synthesis of lanosterol from acetyl-CoA?
Which of the following is not true of the reaction producing malonyl-CoA during fatty acid synthesis?
It requires acyl carrier protein (ACP)
An elevated insulin level in the blood:
stimulates synthesis of fatty acids and triacylglycerols in the liver.
Which hormone(s) trigger the release of neuropeptide Y from orexigenic neurons?
Which statement is false regarding the regulation of HMG-CoA reductase?
Elevated levels of ATP will inhibit HMG-CoA reductase.
Which of the following is not an affect of exercise on metabolism?
Activation of acetyl-coA carboxylase.
Recommended textbook explanations
Fundamentals of Biochemistry
Charlotte W. Pratt, Donald Voet, Judith G. Voet
Lisa A. Urry, Michael L. Cain, Peter V Minorsky, Steven A. Wasserman
Biocalculus: Calculus for the Life Sciences
Campbell Biology (AP Edition)
Cain, Campbell, Minorsky, Reece, Urry, Wasserman
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