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Ch. 9: Energy Metabolism + Membrane Physiology
Terms in this set (19)
After the cell expels its nucleus & organelles, it relies on _________ for energy production.
True/False: Oxygen exchange and oxygen binding to heme iron
What is the main purpose of cation pumps in the RBC membrane?
They maintain high concentrations of intracellular potassium, low concentrations of sodium, and very low concentrations of calcium.
What is the first phase of glucose catabolism?
Glucose is phosphorylated, isomerized, and diphosphorylated to yield fructose-1,6-bisphosphate, which is then converted into glyceraldehyde 3-phosphate (G3P).
What is the second phase of glucose catabolism?
G3P is converted to 3-phosphoglycerate (3-PG). This step generates ATP.
What is the third phase of glucose catabolism?
3-PG is converted to pyruvate, which generates ATP.
What are the 3 shunts from the glycolytic pathway?
1. Hexose Monophosphate Pathway (HMP)
2. Methemoglobin Reductase Pathway
3. Rapoport-Luebering Pathway
What is another name for the hexose monophosphate pathway?
Pentose phosphate shunt
What is the main function of the HMP?
It is an aerobic glycolysis path where accumulated peroxide is detoxified, which extends the lifespan of the RBC.
What is the main function of the methemoglobin reductase pathway?
Methemoglobin reductase quickly reduces oxidized iron.
What is methemoglobin reductase also known as?
Cytochrome b5 reductase
What is the main function of the Rapoport-Luebering pathway?
It generates 2,3-BPG which enhances delivery of oxygen to the tissues
What is RBC deformability?
The ability of RBCs to stretch, undamaged, up to 2.5x their resting diameter due to their high surface:volume ratio.
What are 3 things that RBC deformability relies on?
RBC geometry, membrane elasticity, and cytoplasmic viscocity
The ratio of ______:_______ in the RBC membrane stays relatively constant and balances the need for deformability and strength.
What are glycolipids?
Sugar-bearing lipids that make up part of the RBC external membrane
What are some functions of transmembranous proteins?
They support surface carbohydrates and serve as transport and adhesion sites and signaling receptors.
What are the two principle skeletal proteins of the RBC membrane?
alpha- and beta-spectrin
What is the main function of skeletal proteins in a RBC membrane?
They form a hexagonal lattice adjacent to the cytoplasmic membrane lipid layer and provide
lateral membrane stability
THIS SET IS OFTEN IN FOLDERS WITH...
CH. 6: Cell Structure and Function
CH. 7: Hematopoiesis
Ch. 8: Erythrocyte Production + Destruction
Ch. 8 End of chapter Questions
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