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Naplex Pharmacogenomics

Terms in this set (13)

Abacavir what gene to test?
HLA-B*5701 - hypersensitivity
examples of meds that contain abacavir?
epizcom (Abacavir / Lamivudine)
Triumeq (dolutegravir/abacavir/lamivudine)
Trizivir (abacavir/lamivudine/zidovudine)
CBZ, oxcarbazepine, phenytoin which gene to test
HLAB 1502 (asians esp) - hypersensitivity (SJS/TENS)
Azathioprine which gene to test
TPMT, if LOW activity --> myelosuppression
Cetuximab (Erbitux), panitumumab (Vectibix) (for colon cancer) what mutation to test?
KRAS NEGATIVE --> CAN receive drug
if positive mutation, they won't respond --avoid
Trastuzumab (herceptin) what to test for? (breast cancer)
also for pertuzumab (Perjeta), Lapatinib (Tykerb)
HER2 receptor overexpression
clopidogrel test for what?
cyp2C19 (clopidogrel is prodrug)
*1 - normal metabolism
2 or 3 - will NOT convert to active form (poor metabolizers) --> higher CV event rate
codeine metabolism?
to MORPHINE by Cyp2D6
what is CPIC?
Clinical Pharmacogenetics Implementation Consortium
warfarin enzyme and gene?
2C9 - if 2 or 3, then increased risk of bleeding. If DIMINISHED response from 2C9, then increase risk of bleed bc less warfarin converted to INACTIVE metabolite - lower dose of warfarin

VKORC1 G>A : increased risk of bleed; if pt produces LESS VKORC1, then will need LOWER dose of warfarin
what are the isomers of warfarin?
S isomer is more potent than R, and is metabolized by 2C9
allopurinol testing?
HLAB 5801 - if positive, then increase risk of skin reactions (SJS/TENS)
capecitabine and 5FU what gene to test?
if DPD DEFICIENT, then increase risk of toxicity (diarrhea, neutropenia, neurotoxic)
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