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what causes altered absorption?

Diminished HCl
Increased transit time through GI tract
Decreased absorption of medications requiring active transport

what are drugs requiring active transport

calcium, iron, vitamin B12

what causes changes in distribution?

decreased total body water
increased body fat

what is of note in malnourished elderly?

may have decreased albumin resulting in increased concentrations of highly protein-bound drugs

what is a drug with a narrow therapeutic index?


what is altered in liver metabolism?

phase 1 reactions:

what is altered in excretion?

renal elimination

what is the main drug requiring renal elimination?


what creatinine clearance requires dose adjustment?


what does coumadin interact with in seniors?


what do ace inhibitors interact with in seniors?


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