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11 terms

Ph- Geriatrics

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what causes altered absorption?
Diminished HCl
Increased transit time through GI tract
Decreased absorption of medications requiring active transport
what are drugs requiring active transport
calcium, iron, vitamin B12
what causes changes in distribution?
decreased total body water
increased body fat
what is of note in malnourished elderly?
may have decreased albumin resulting in increased concentrations of highly protein-bound drugs
what is a drug with a narrow therapeutic index?
phenytoin
what is altered in liver metabolism?
phase 1 reactions:
oxidation
reduction
hydrolysis
what is altered in excretion?
renal elimination
what is the main drug requiring renal elimination?
antibiotics
what creatinine clearance requires dose adjustment?
30ml/min
what does coumadin interact with in seniors?
NSAIDs
antibiotics
dilantin
what do ace inhibitors interact with in seniors?
potassium
aldactone