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Leukoplakia-Erythroplakia

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Precancerous Lesions

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Terms in this set (19)

Precancerous Lesions

• Leukoplakia
• Proliferative verrucous leukoplakia (PVL)
• Erythroleukoplakia
• Erythroplakia
• Actinic keratosis
• Lichen planus ?
• Oral submucous fibrosis

A white patch or plaque that cannot be characterized clinically or pathologically as any other disease. (W.H.O)
As a term it does not define precisely a lesion but it excludes several entities.
1.5-4.3% worldwide prevalence

Leukoplakia is a premalignant lesion

1. A large number of carcinomas has been associated
with leukoplakic changes.
2. In prospective studies, occurrence of malignant
transformation in oral leukoplakias has exceeded the
number of oral cancers expected in the general
population.
3. (4%-47% estimated lifetime risk)
4. 70% male predilection

Presence of dysplastic changes in leukoplakic lesions

• 5-25% of biopsy samples

Epithelial Dysplasia and Leukoplakia

•Occurrence and time of dysplastic changes is uncertain.
•An erythematous component and discomfort should
raise suspicion.
•Dysplasia increases the risk for SCCa and surgical
excision is required. This precludes prospective followup
studies.