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Hypersensitivity States (26)

Terms in this set (27)

True or False: In an anaphylactic reaction, the first treatment that should be given is an antihistamine.
false

adrenaline
True or False: Type 2 hypersensitivity reactions are characterized by immune complex deposition in tissues.
false

type 3
What type hypersensitivity is allergic rhinitis?
type 1 hypersensitivity
Review IgE-dependent release of inflammatory mediators.
1
Name 3 causes of allergic rhinitis.
mold

pollen

dust mites
Allergic rhinitis Rx (4)
cromolyn sodium (mast cell stabilizer)

anti-histamines (non-sedating preferred)

intranasal steroids

leukotriene receptor antagonists
Name some symptoms of allergic rhinitis.
runny nose

cough

itchy eyes, ears, throat (red)

sneezing

headache

nasal congestion

drowsiness; 2
Review hypersensitivity type 1.
3
Review hypersensitivity type 1 sensitization phase.
4
Type 1 hypersensitivity Rx
epinephrine
What is the most effective prophylactic pharmacological intervention for type 1 hypersensitivity?
chronic topical steroid
Review hypersensitivity type 1 desensitization.
5
Review immunotherapy.
6
Review hypersensitivity type 2.
7
Describe the sensitization phase of type 2 hypersensitivity.
production of IgG or IgM antibodies specific for a cell surface antigen; 8
Name 3 modes of destruction in type 2 hypersensitivity.
complement (MAC or opsonin)

IgG opsonin-phagocytosis

NK cells (ADCC)
Name 4 clinical manifestations of hypersensitivity 2.
transfusion reactions

hemolytic disease of the newborn

autologous cell destruction (autoimmune disorders)

chronic "idiopathic" urticaria
Name an antibody to Rh antigens.
RhoGAM
Name the disorder: glomerular and pulmonary basement membrane antigens.
Goodpasture's syndrome
Review transfusion reactions.
9
Review development of erythroblastosis fetalis.
10
Review hypersensitivity type 3.
11
Describe the sensitization phase in type 3 hypersensitivity.
production of IgM and IgG antibodies to a soluble antigen

immune complex formation

persistent antigen exposure; 12
Review type 3 hypersensitivity effector phase.
13
Name 4 examples of type 3 hypersensitivity.
Farmer's lung

rheumatoid arthritis

systemic lupus erythematosus

serum sickness (systemic)
Review antigen:antibody complexes.
14
Review hypersensitivity 3 chart.
15
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