33 terms

Transplantation (28)

STUDY
PLAY
True or False: Transplanting a porcine heart valve into a human is an example of a xenotransplant.
true
True or false: Graft rejection occurs more quickly with a second transplant from the same donor since graft rejection results in immunological memory.
true
True or False: Graft versus leukemia effect is largely dependent on T cells or T cell derived cytokines.
true
Review classification of grafts.
1
Review tissue typing: micro-cytotoxicity assay.
2
Review testing for MHC-2/1 differences.
3
Name the 3 classes of graft rejection.
hyperacute

acute

chronic
Describe time course and cause of hyper-acute graft rejection.
minutes-hours

preformed anti-donor antibodies and complement
Describe time course and cause of accelerated graft rejection.
days

reactivation of sensitized T cells
Describe time course and cause of acute graft rejection.
days-weeks

primary activation of T cells
Describe time course and cause of chronic graft rejection.
months-years

causes unclear: antibodies, immune complexes, slow cellular reactions, recurrence of disease
Name the effector cells in acute graft rejection.
T cells
Hyperacute rejections are primarily _____ mediated.
antibody
Review hyperacute rejection.
4
Which class of graft rejection is associated with type 2 cytokines?
chronic rejection
Describe delayed hyperacute graft rejection.
associated with activation of endothelial cells, thrombosis, procoagulants
Which class of graft rejection is associated with type 1 cytokines?
acute rejection
What cells are involved in acute graft rejection?
T cells
Review immunological memory of graft rejection.
5
Describe the general actions (3) of chemokines and cytokines in graft rejection.
activate vascular endothelial cells

enter circulation

alter vascular permeability
Review graft rejection: activation of endothelial cells.
6
Review neutrophil and monocyte action in graft rejection.
7
Review effects of chemokine and cytokine entrance into circulation in graft rejection.
8
Review alteration of vascular permeability by chemokines and cytokines in graft rejection.
9
Review destruction of graft cells by osmotic lysis in graft rejection.
10
Review role of CD4+ T cells in graft rejection.
11
Review 2 types of alloantigen presentation.
12
Name 3 organ transplants that can cause graft versus host disease.
bone marrow

intestine

live
Name some symptoms of GvHD.
skin sloughing

diarrhea

inflammation

rash; 13
What is the primary cure for chronic myelogenous leukemia?
bone marrow transplantation
Which cells are involved in graft versus leukemia in chronic myelogenous leukemia?
T cells
Name 2 cytokines involved in graft versus leukemia in chronic myelogenous leukemia.
IL-3

GM-CSF
Name 3 approaches towards specific immunosuppression for transplantation.
block CD40-CD40 ligand interaction

CTLA Ig to block CD80/CD28

CD200-CD200 receptor