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True or False: Transplanting a porcine heart valve into a human is an example of a xenotransplant.
True or false: Graft rejection occurs more quickly with a second transplant from the same donor since graft rejection results in immunological memory.
True or False: Graft versus leukemia effect is largely dependent on T cells or T cell derived cytokines.
Review classification of grafts.
Review tissue typing: micro-cytotoxicity assay.
Review testing for MHC-2/1 differences.
Name the 3 classes of graft rejection.
Describe time course and cause of hyper-acute graft rejection.
preformed anti-donor antibodies and complement
Describe time course and cause of accelerated graft rejection.
reactivation of sensitized T cells
Describe time course and cause of acute graft rejection.
primary activation of T cells
Describe time course and cause of chronic graft rejection.
causes unclear: antibodies, immune complexes, slow cellular reactions, recurrence of disease
Name the effector cells in acute graft rejection.
Hyperacute rejections are primarily _____ mediated.
Review hyperacute rejection.
Which class of graft rejection is associated with type 2 cytokines?
Describe delayed hyperacute graft rejection.
associated with activation of endothelial cells, thrombosis, procoagulants
Which class of graft rejection is associated with type 1 cytokines?
What cells are involved in acute graft rejection?
Review immunological memory of graft rejection.
Describe the general actions (3) of chemokines and cytokines in graft rejection.
activate vascular endothelial cells
alter vascular permeability
Review graft rejection: activation of endothelial cells.
Review neutrophil and monocyte action in graft rejection.
Review effects of chemokine and cytokine entrance into circulation in graft rejection.
Review alteration of vascular permeability by chemokines and cytokines in graft rejection.
Review destruction of graft cells by osmotic lysis in graft rejection.
Review role of CD4+ T cells in graft rejection.
Review 2 types of alloantigen presentation.
Name 3 organ transplants that can cause graft versus host disease.
Name some symptoms of GvHD.
What is the primary cure for chronic myelogenous leukemia?
bone marrow transplantation
Which cells are involved in graft versus leukemia in chronic myelogenous leukemia?
Name 2 cytokines involved in graft versus leukemia in chronic myelogenous leukemia.
Name 3 approaches towards specific immunosuppression for transplantation.
block CD40-CD40 ligand interaction
CTLA Ig to block CD80/CD28
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