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third line of defense
acquired with exposure to foreign substance; produces protective antibodies and creates memory cells-specific
Fnx's of a healthy functioning immune system:
surveillance of the body, recognition of foreign material, destruction of entities deemed to be foreign
55%-90% of wbc's, multilobed nuclei;small purple granules containing digestive enzymes. FNX is general phagocytosis. Life span 2 days,w with only 4-10 hours spent in circulation
1%-3% wbc's, Bilobed nucleus w/ lg orange granules containing toxic proteins, inflammatory mediators,and digestive enzymes. FNX is destruction of lg eukaryotic pathogens such as worms and fungi. Found in higher #'s in spleen and bone marrow.
0.5%of wbc's, pale staining contricted nuclei w/ dark blue-black granules. FNX respond to lg eukaryotic pathogens and recruit other leukocytes. Cytoplasmic granules contain histamines,prostaglandins,and chemical mediators of the allergic response.
3%-7%wbc's, largest WBC;nuclei lg,ovoid, and often indented--no cytoplasmic granules visible. FNX phagocytosis, followed by final differentiation into macrophages and dendritic cells. Monocytes also secrete chemicalks that moderatwe the fnx's of the immune system.
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