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Psychopharm (1/19) exam 1

Terms in this set (14)

Drug -

which drugs must have regulatory approval?

what substances are don't require regulatory approval?
-substance (other than food) that causes a biological response and is usually used for treatment.

-Rx drugs (e.g., FDA); includes generic and name-brand

-OTC drugs and dietary and herbal supplements are NOT formally approved through the FDA
Small molecule drugs -

Biologics -

Why does size matter? What amount of restriction does this impose?
-less than 1 kDA (kilo dalton). Oral.

-Vaccines, blood and blood components, allergenic, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins.
Explain how it is usually bench to bedside, but often bedside to bench.

ex?
...
Exogenous drugs -

often inspired by what? ex?

endogenous drugs? ex?

Generated: ____________(ex)

Found: ____________ (ex)

regardless of source, all drugs work how?
...
What are the 2 general classes of drugs?
...
agonist -

ex?

antagonist -

ex?
...
generic name (i.e., ________) -
ex?

trade name (i.e., _________)-
ex?

chemical name -

street name -
...
ODLU -

is it common? is it regulated by the FDA?

what patient populations is it most common in?

why does it occur?
...
drug development can take as long as _____ years, and cost upwards of $__ billion

developing a new medicine takes an average of ___ to ___ years

why? (4 reasons)
...
in preclinical testing, in vitro means what? in vivo?

during the preclinical testing phase, between ___ and ___% of the compounds are haunted due to _____________.
...
For in vivo animal models, domesticate rats (Rattus norvegicus) were significant in science why?

what was the first strain?

what are the most common lab animals used today?
...
Who are Francois Magendie and Claude Bernard?
...
3R's: Philosophy Toward Animal Research -
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What are the issues with modeling psychiatric disorders?
(1)
(2)
(3)
(4)
(5)
(6)
(7)
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