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32 terms

cell cycle

STUDY
PLAY
s phase
duplication of chromosome (10-12 Hr)
M PHASE (mitosis)
separation of DNA/nucleus and separation of cytoplasm (1 hr)
interphase
include the phases that prepare cells for growth and division
g1 phase
gap phase or growth phase (proteins produced for organelle production)
g2 phase
gap phase or growth phase (proteins produced for mitosis)
g2M checkpoint
is all DNA replicated? is environment favorable
enter mitosis, trigger early mitotic events that lead to chromosome alignment on the spindle in metaphase
Metaphase to anaphase transition
are all chromosome attached to the spindle? stimulate sister-chromatid separation, leading to mitosis and cytokinesis
start checkpoint
is environment favorable? occurs in late g1 where the cell commits to cell cycle entry and chromosome duplication
robust and reliable
the system is ___ in that many assurances are in place to operate under various conditions
adaptable
the system is ___ in that it is found in specific cell types and responds to specific signal
cyclin
__ forms a complex with cyclin dependent kinase to trigger cell cycle event
cdks
_ are inactive with cyclins
cyclin dependent kinase
protein kinases that rise and falls as the cell progresses through the cell cycle at specific events
cyclins
cdk regulators that must be bound to cdks for activity
cyclin-cdk complex
triggers and activates cell cycle events
g1/s cyclins
activate cdks in late g1 to trigger progression through start resulting in commitment to cell cycle entry
s cyclins
binds cdks after progression through start to help stimulate chromosome duplication
m cyclins
activate cdks that stimulate entry into mitosis at g2/m checkpoint
g1 cyclin
helps govern activities of the g1/s cyclins which control progression through start in late g1
cki p27
cdk inhibitor protein, regulate cyclin-cdk complexes by binding to the complex via the cdk active site rendering it inactive
g1-cdk
favorable extracellular environment
g1/s-cdk and s-cdk
dna damage
m-cdk
unreplicated dna and dna damage
apc/c
chromosome unattached to spindle
CYCLIN D
CDK4, CDK6
CYCLIN E
CDK2
CYCLIN A
CDK1, CDK2
CYCLIN B
CDK1
G1 CDK
CYCLIN D
G1/S CDK
CYCLIN E
S-CDK
CYCLIN A
M-CDK
CYCLIN B