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what two boosters are used with PIs?
MOA of ritonavir
MOA of cobicistat
note: only approved to enhance atazanavir and darunavir (the 2 more popular PIs)
BBW ritonavir vs. cobicistat
BBW: interacts with many medications = life threatening AE (arrhythmias, etc.)
no BBW with cobicistat
both ritonavir and cobicistat have antiretroviral activity
false - only ritonavir does
remember: cobicistat works by being an inhibitor = increases levels
pgp inhibition ritonavir vs. cobicistat
both ritonavir and cobicistat should be taken with food
co-formulation considerations ritonavir vs. cobicistat
R: hard to co-formulate
C: can be co-formulated (ex. Stribild, Genvoya, Prezcobix, Evotaz, Symtuza)
drugs that are CI with ritonavir and cobicistat
- st. johns wort
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