Vitamin B5 , B6, B7

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Vitamin B5 is also called pantothenic acid
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Vitamin B5 is also called pantothenic acid
True
Succinyl CoA contains which vitamin
Vitamin B5
Which is major role of Vitamin B5 in body
It is essential component of CoA , is a carrier of acyl groups.
Deficiency of Vitamin B5 leads to ....
Burning feet syndrome ( burning and aching of feet)
dermatitis
alopecia
adrenal insufficiency
weakness
numbness
sleep disturbances
Different forms of Vitamin B6 are :
pyridoxine, pyridoxal, pyridoxamine
Coenzyme form of vitamin b6 IS
pyridoxal phosphate
PLP is coenzyme for which enzymes/reactions
1) Transamination reactions
2) Decarboxylation - Dopa decarboxylase ( metabolism of Dopamine), Histidine decarboyxlase.
3) Glycogen phosphorylase( Glycogen breakdown)
4) ALA synthase for Heme synthesis
5) Neurotransmitter formation- Norepinephrine, epinephrine, histamine,Dopamine, Serotonin.
Vitamin B 6 deficiency leads to :
1) Peripheral neuropathy
2) Sideroblastic anemia
3) Convulsions, hyperirritability, restlessness
4) hyperhomocysteinemia
A 30-year-old male presents with symmetrical paraesthesias in arms and legs. His lab investigation reveals presence of sideroblasts in peripheral smear. He has history of TB and is currently taking isoniazid. What is most likely cause of his symptoms?
Vitamin B6 deficiency
He should be supplemented with vitamin B6

Isoniazid interferes with metabolism of vitamin B6 and causes vitamin B6 deficiency in body.
- Vitamin B6 is required for ALA synthase--> which is rate limiting enzyme for Heme synthesis--> Decreased heme synthesis--> formation of sideroblasts ( nucleated erythoblasts with deposition of iron around nuclei ( Last step of heme synthesis involves incorporation of iron...since heme is not synthesized...the iron is deposited in red blood cells)
- Parasthesia is abnormal sensation as numbness, tingling , pain ( indicative of sensory peripheral neuropathy seen in vitamin B6 deficiency.
Image: A 30-year-old male presents with symmetrical paraesthesias in arms and legs. His lab investigation reveals presence of sideroblasts in peripheral smear. He has history of TB and is currently taking isoniazid. What is most likely cause of his symptoms?
What is interaction of L-dopa with Vitamin B6 in parkinson disease patient
- Do not give B6 with L dopa
Parkinson disease is caused by deficiency of dopamine in brain --> so you give dopamine from outside ( as L-dopa)
If patient takes lot of Vitamin b6--> it will degenerate L dopa ( thru DOPA decarboxylase which is vitamin b6 dependent enzyme ) and less of it will be available to brain and so it will worsen the symptoms of parkinson disease.
A 20 year old HIV positive male is started on directly observed therapy ( DOT) with cycloserine for tuberculosis. Concomittant supplementation of which of the vitamins is neededVitamin B6 Cycloserine is an antibiotic used for treatment of TB and UTI It causes vitamin B6 deficiencyVitamin B7 is also known asBiotinBiotin is required as coenzyme for which class of enzymesCarboxylases ( Carboxylation reactions involve addition of one carbon )