low birth weight, higher miscarriage, placental abruption and previa, IUGR, prematurity;
-cleft lip, palate
-associated with asthma, otitis media, wheezing, and other sinopulmonary ailments
-increased risk of SIDs
-behavioral: adhd, IQ, language deficits, etc.
carbamazepine, valproic acid, phenytoin;
2. IUGR, microcephaly, anticonvulstant face which is broad bridge of nose, small anteverted nostrils, and long upper lip; fingernail hypoplasia; cardiac defects, cleft lip, hyospadias, cryptoorchidism, clubfoot
3. valproic acid and carbamazepine
4. valproic acid
-Mucocutaneous pigmentation of lips and gums that starts in infancy around mouth,nostrils, and buccal mucosa
-hundreds of polyps in stomach and colon
-Risk of intussusception, colon CA; risk of CA in many other organs including colon, pancreas, stomach, lung, testes, breasts, uterus, ovary, cerviz; 70% risk by 70;
-Tx: routine colonoscopies removaing any mean looking polyps plus screening
MC Rheumatologic disease of childhood
2. presents with?
3. joints MC
4. which test is almost always positive and which is not helpful?
5. which type: 5 or more joints in first 6 months, typically smaller joints and F; symmetric
6. 4 or fewer joints, ANA+, very young females, uveitis that is chronic, Boys with this type of usually HLA-B27 positive
7. this type, aka stills disease, affects males and females equally, extraarctiular involvement is common, contains most JIA deaths; look out for fever, leukocytosis, HSM, rash, LAD, pericarditis
8. gold standard for therapy