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Chemistry Test 1
Terms in this set (13)
What are xenobiotics?
Foreign chemicals that the body does not produce.
Between Bioactivation and Detoxification, which is the desired vs. the undesired process.
Detoxification is Desired and leads to excretion.
Bioactivation is undesired and eventually leads to carcinogenicity, mutagenicity and teratogenicity.
The plasma concentration of drugs, reactive intermediate formations, routes of administration and dosages are all dictated by _____________?
Which CYP enzyme bioactivates the procarinogen benzo(a)pyrene into a potential carcinogen?
What CYP enzymes promote the detoxification of Estradiol, and where are they primarily located?
CYP1A1 (extraheptatic = not in the liver)
CYP1A2, CYP3A4 (Liver)
What CYP Enzymes promote the Bioactivaton of Estradiol and where are they primarily located?
CYP1B1 (Estrogen-target tissues such as ovary, uterus and mammary glands)(abundantly expressed in tumor cells)
Acyclovir is an an antiviral prodrug. What is the active form of this drug?
What phase includes oxidation, hydroxylation, epoxidation, reduction and hydrolysis reactions?
Phase 1 Reactions
What phase includes conjugation, glucuronic acid, sulfate, amino acids reactions?
Phase 2 Reactions
What genetic factors is a mutation in CYP2D6 linked with? What genetic factors is a mutation in CYP2C19 linked with?
A mutation is CYP2D6 is linked with metoprolol toxicity and a mutation in CYP2C19 polymorphism is linked to omeprazole toxicity.
What induced lupus effect does slow/fast N-acetylation have of on Procainamide?
If the N-acetylation of Procainamide is slow, there is a higher incidence of Procainamide-induced lupus and vice versa.
Which are the following are factors that affect metabolism?
a) Physiological Factors
b) Pharmacokinetic/ Pharmacodynamic Factors
c) Environmental Factors
d) All of the above
e) None of the above
D) All of the above
Cytochrome P450 is a monooxygenase system present both in the liver and extrahepatic tissues responsible for the metabolism of drugs and xenobiotics. To do so it utilizes the NADP/ NADPH redox system. How many binding sites does this enzyme have?
This enzyme has 2 binding sites. 1) The xenobiotic binds to the hydrophobic side. 2) molecular oxygen binds to the hemeside
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