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Bladder Dysfunction Pharm

Terms in this set (66)

Risk factors for urinary incontinence
Delerium & dementia
Infections
Atrophic vaginitis, atropic urethritis, atonic bladder
Psychological causes (depression), pharmacological agents
Endocrine (diabetes, hypothyroidism)
Restricted mobility
Stool impaction
Types of urinary incontinence
Overflow
Stress
Urge
Mixed
Functional
Urge incontinence
-involuntary leakage of urine with a sudden, strong desire to urinate
-most common cause of I/C in elderly
-Associated w/ bladder muscle overactivity (age related, neurogenic, or bladder infection)
Urge incontinence/overactive bladder treatment
Lifestyle interventions
Behavioral interventions
Toileting program (bladder retraining)
Pelvic flood muscle exercises
E-stim (transvaginal electrical stim)
Surgery
Urge incontinence/overactive bladder treatment: Anticholinergic medications
Oxybutynin (Ditropan)
Solifenacin (Vesicare)
Tolterodine (Detrol)
Trospium (sanctuary
Anticholinergic MOA

MUST KNOW
Competitively inhibit muscarinic receptor in bladder→ relaxes detrusor muscle
Anticholinergic medication ADRs
Blurry vision
Dry mouth
Constipation
Tachycardia
Impairs cognitions nd memory

think dry dry dry
Oxybutynin modes of admin
Transdermal patch
Topical gel
Solifenacin dosing considerations
Lower dose (5mg) w/:
-moderate liver impairment
-CrCl <30 ml/min
-CYP3A4 inhibitors

Caution with QT prolongation
Urge incontinence/overactive bladder treatment: Antispasmotic medications
Mirabegron (Myrbetriq)
Mirabegron (Myrbetriq) MOA
selective beta3 agonist
relaxes detrusor muscle
Mirabegron (Myrbetriq) ADRs
Hypertension
Headache
UTIs
Nasopharyngitis
Stress incontinence
-occurs with coughing, sneezing, laughing, climbing stairs, bending, etc. → increase in abdominal pressure
Causes of stress incontinence
-Weakened pelvic floor muscles (pregnancy, surgery, etc)
-Urethral hypermobility
Stress incontinence treatment
-Pelvic floor muscle exercises
-Lifestyle interventions
-Toileting programs
-Support devices (pessaries, impressa)
-Medications
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