8 terms

Neuro F2

Mesolimbic DA System Anatomy:
• Ventral Tegmental Area produces DA
• Projects to NUCLEUS ACCUMBENS & cortex
Mesolimbic DA System Associations:
• Incentive-motivated behavior
• Additive and reinforcing properties
DA Model of Drug Addiction (3 Phases):
• Binge
• Crash
• Relapse
DA Model of Drug Addiction (Binge):
• First High
• Sharp incline in DA levels
• Followed by DA depletion down to baseline (0)
DA Model of Drug Addiction (Crash):
• Level of DA drops below baseline (0)
• Followed by slight (not total) DA recovery period
DA Model of Drug Addiction (Relapse):
• Increase in DA level but starts below baseline (0)
• Not as good as first high
Decreased Serotonin (5-HT) Function Hypothesis:
• *Global decrease in 5-HT
• Potent antidepressant drug effects suggest global decrease of 5-HT function
NOT always effecting
• Prozac (Fluoxetine)
• Zoloft (Sertraline)
• Celexa (Citalopram)
• Paxil (Paroxetine)
• Luvox (Fluvoxamine)