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Unit 3, Lecture 12- Pain/Nociception
Terms in this set (21)
ATP, Bradykinin, ATP, H+, K+,
Predominant nociceptive signaling molecules (4)- PNS nociception
hyperalgesia, allodynia, central sensitization
3 types- nociceptive sensitization
2 types- chronic pain
pain that is felt in a location other than where the pain originates- primary afferents merge at common secondary afferents.
the perception (not including emotional component) of pain-causing stimuli
− the neural encoding of stimuli that damage or threaten to damage normal tissue
" encompasses both the somatic and emotional components of pain as a result of actual damage or perceived damage to the body.
PNS nociceptive signaling molecule; directly depolarizes the nociceptive cell
PNS nociceptive signaling molecule; activates acid-sensing ion channel (ASIC and VR1/TRPV1)
PNS nociceptive signaling molecule; binds to purinergic receptors
PNS nociceptive signaling molecule; a neuropeptide that binds to BK2 receptors (bradykinin also modulates nociceptors)
There is also a classic mechanosensitive channel involved, but its' identity is unknown at this time.
Ad, C fibers
Two types of pain neurons
smallest diameter myelinated afferent; respond to either nociceptive mechanical stimuli or mechanical and thermal stimuli
smallest diameter fiber and unmyelinated; typically response to nociceptive mechanical, thermal and chemical stimuli - said to be polymodal nociceptors.
transmit 1st Pain, the early sharper component of a painful stimulus (transient, localized and better tolerated).
transmit 2nd Pain, the later component of a painful stimulus (longer lasting, more diffuse, less tolerated
There are different sensory receptors for detecting non-painful versus painful thermal stimuli.
Non-nociceptive thermoreceptors respond at lower temperatures, but their response saturates when the temperature reaches the painful levels (TRPV3 & 4 detect warm temps).
Nociceptors only respond when the increase in temperature reaches a certain threshold.
Responds to H+; chemical mechanosensory response
vanilloid receptors (VR-1), TRPV1, TRPV1
Nociceptive thermal stimuli are detected by heat-activated ions channels called _____________________ or transient receptor potential vanilloid 1 (_______) channel.
Are part of a larger family of TRP channels that have members that respond to light, cold & heat.
Also responds to capsaicin (plant compound), why spicy food imparts a sensation of heat.
Also respond the H+, so may contribute to nociceptive mechanosensory response.
___________ channels rapidly desensitize, which is why capsaicin applied to the skin has analgesic properties.
Nociceptive spinal pathways, dorsal horn, dorsal horn, dorsal horn neurons, contralateral
When nociceptive afferents enter the spinal cord they bifurcate (fork) to form tracts that ascend and descend 1-2 spinal segments (tract of Lissauer).
Axon collaterals branch off from this tract and enter the dorsal horn.
In the ________ ________, these afferents synapse onto 2nd order nociceptive neurons, primarily in the superficial lamina of the _________. __________(lamina I & II).
Axons from the 2nd order neurons (called _______. _______. ______) project to the ___________ side and then ascend up the spinal cord (via the spinothalamic tract) to the brainstem, thalamus and cerebrum.
The pathway that carries nociceptive stimuli up the spinal cord is sometimes referred to as the spinothalamic tract and sometimes referred to as the anterolateral column.
The anterolateral column contains both axons that carry pain signals (spinothalamic tract axons) and axons that carry non-nociceptive temperature signals and a nondiscriminative form of touch information (these 2ndorder neurons also cross the midline like the 2nd order pain axons).
We will use the term spinothalamic tract.
medulla, right away
X-over: non painful @_______.
VPL of thalamus
Destination- both painful and non-painful stimuli if coming from limbs and trunk of body
-As with the somatosensory cortex- (this term) projects to the somatosensory cell
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