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increased nuclear size. Cells with nuclei larger than 10u in diameter suggest malignancy
Increased nucleus:cytoplasm ratio
Normal nonlymphoid cells usually have a N:C of 1:3 to 1:8 depending on the tissue. Ratios > or = 1:2 suggest malignancy
Variation in nuclear size. This is especially important if the nuclei of multinucleated cells vary in size
multiple nucleation in a cell. This is especially important in the nuclei vary in size.
Coarse chromatin pattern
the chromatin pattern is coarser than normal. It may appear ropy or cord-like
Nucleoli are increased in size. Nucleoli > = 5 strongly suggest malignancy. For reference RBC are 6-7u
Nucleoli are fusiform or have other angular shapes, instead of their normal round to slightly oval shape
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