Bordatella pertussis toxin
Gram (-) aerobic bacillus, causes whooping cough (coughing, choking spells, and gasping for air);
Toxin inactivates inhibitory subunit of the G protein complex, activating adenylate cyclase, increasing cAMP in the cells of the respiratory system >> EDEMA. Toxin also causes LYMPHOCYTOSIS by blocking chemokine receptors, blocks the function of immune effector cells and increases HISTAMINE SENSITIVITY. Toxin also alters hormonal pathways regulated by cAMP, increasing insulin secretion, causing HYPOGLYCEMIA.