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Late tissue reactions chapter 9 pt 1

Terms in this set (25)

Give 3 examples of late biologic tissue damage
Cataracts
Leukemia
Genetic mutations
Non genetic consequences of radiation exposure that appear months or years afterward
Late tissue reactions
Mutational or randomly occurring biological changes, independent of dose. Examples include cancer and genetic effects

Also called probabilistic effects
Stochastic effects
Any radiation effects on organs/organ systems that increase with increasing dose. May occur as early effects, immediately after irradiation, or late effects, after some latent period.
Tissue reactions
Science that deals with the incidence, distribution, and control of disease in a population
epidemiology
Graph that demonstrates observed effects of radiation exposure in relation to the dose of radiation received
DR curve (Radiation dose-response relationship)
A point or level at which a response to an increasing stimulation first occurs
Threshold
How would a linear non threshold DR curve look?
Like a straight line
How would a linear quadratic DR curve look to represent stochastic and hereditary effects?
Upward curved line
Acute reactions from significant radiation exposures are represented through what kind of curve?
Linear threshold dose- response curve
High dose cellular responses from Radiation therapy are demonstrated using what curve?
Sigmoid, S-shaped threshold curve
What type of curve is used for most types of cancers
Linear non threshold (LNT) curve
What type of curve demonstrates risks associated with low level radiation other than cancer
Linear quadratic non threshold (LQNT) curve
What type of curve demonstrates late tissue reactions
Linear threshold curve
What type of curve demonstrates high dose cellular responses to radiation therapy
Sigmoid S-shaped curve
Somatic effects can be classified into what two subdivisions?
Stochastic effects
Tissue reactions
When the probability of the effect happening depends on the dose but the severity doesn't

Ex. Cancer
Stochastic effects
When the probability and the severity of the effect depend upon dose

Ex. Cataract
Tissue reactions
An effect in the offspring of the individual who was irradiated

Ex. Irradiation of genetic material (sperm or egg) leading to genetic malformation of offspring
Non-somatic effect
Consequences of radiation exposure that appear months or years after such exposure

May be stochastic or tissue reactions
late somatic effects
The following are all examples of _______

Cataracts
Fibrosis
Organ atrophy
Loss of parenchyma cells
Reduced fertility
Sterility
Late tissue reactions
The following are all examples of _____

Cancer
Genetic (hereditary) effects
Stochastic effects
What are the 3 major types of late effect?
Carcinogenesis
Cataractogenesis
Embryologic effects (birth defects)
The 3 major types of late effects include:

Carcinogenesis
Cataractogenesis
Embryologic effects (birth defects)

Which are considered stochastic and which are late tissue reactions?
Stochastic: carcinogenesis and embryologic effects

Late tissue reaction: cataracts
What type of curve is used for current radiation protection philosophy?
Linear non threshold dose (LNT) curve
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