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One Health III Lecture 7
Terms in this set (25)
A protein that can fold in multiple, structurally distinct ways, at least on eof which is transmissible to other prion proteins
Potentially play a role in protecting cells and helping them respond to oxygen deficiency
Prions are unique pathogens in that they appear to have no ________ ______ and thereby differ from viruses, bacteria, fungi and other pathogens
Because prions are an abnormal form of protein that is genetically encoded, they do not produce an ________ _______
Prion protein causing other proteins to fold into a form called PrPsc is named after what, which was the first TSE discovered
Prions are ______ _______ to disinfectants, heat, UV light, Ionizing radiation and formalin
TSE in cattle
Bovine Spongiform Encephalitis "Mad Cow"
TSE in Sheep
TSE in wild ruminants
Chronic Wasting Disease
TSE in humans
Kuru, Cruetzfeldt-Jacobs Disease
T/F TSEs can be identified by seroconversion or serologY
Histopath on brain tissue
The definitive diagnosis of TSEs is generally made through
1986 in Great Britan
When did BSE first appear?
After peaking in 1992, the number of cases in 2011 was ___
Do date, the cost of 6 cows with BSE in the US has cost nearly ___ _________ in lost exports
Progressive degeneration of nervous system, abnormal posture, incoordination, decreased milk production
What are the signs of BSE in cattle?
The incubation period of BSE in cattle is what
Research indicated that BSE _______ be transmitted in cows milk
The primary animal-health protective measure is what?
Regulations prohibiting the feeding of most mammalian proteins to ruminants what enacted when and by what organization?
Feed ban and primary control measures
In 2011 there were only 29 BSE cases, representing a 99% reduction since the peak in 1992 of 37,331 cases. This is primarily due to what measures
Weight loss, Behavioral changes, wool pulling, biting at limbs or side, bunny hopping, increased sensitivity to noise and movement
What are the clinical signs of Scrapie in sheep?
As of June 7, 2019, CWD in free-ranging deer, elk and or moose has been reported in at least ___ US states
Conversion of human prion protein by CWD-associated prions has been demonstrated __ _____
Kuru in New Guinea is a very rare disease that is caused by an infectious protein found in contaminated _____ _______
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