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Genetics ch. 11 lecture
Terms in this set (13)
How do bacteria package DNA?
Nucleoid region to package DNA
-supercoil DNA (twist, torsional strain)
no histone proteins
Know different stages of chromosome compaction and know that they are very compact
nucleosomes, solorsomes, then loops then rosettes,
Why do we compact chromosome?
- full compaction because we need to put chromosomes in a state to move during mitosis
- lower order condensation is to regulate gene expression by making DNA inexcessible
How do we replicate DNA with nucleosomes present?
They are removed by the front end of the replication apparatus and quickly reassemble behind the daughter strand via dimers.
long - q arm
short - p arm
Know chromosome shapes
In situ (in place)
molecular probe & some form of DNA
chromosomes are not uniformly distributed within a nucleus
What are inter chromosomal domains for?
regions between territories; pathways for stuff to get in
Chromatin remodeling & epigenetics
Change DNA but they don't change DNA sequence
How do these modifications happen?
happen to histones and take place on the N-terminal ends of the proteins.
Methy groups can be added - tighten up DNA packaging and reduce transcriptional activity
Acetyl groups can be added -
Are epigenetic modifications inheritable?
yes turned off and turned on genes can be inherited because of retention of some old histones during DNA replication.
How are X chromosomes inactivated?
The Xist gene is active on the heterochromatic X and inactive on the euchromatic X
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