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ID: Test 1 Study Set

Terms in this set (44)

when the MIC value is at or below "S" breakpoint; organism will most likely be eradicated with normal doses of the antibiotic:

A: Susceptible (S)
B: Intermediate (I)
C: Resistant (R)
a
when the MIC is above the "S" breakpoint but below "R" breakpoint; treatment may be successful using maximal antibiotic doses or alternative dosing schedules/strategies or in areas of high antibiotic concentration:

A: Susceptible (S)
B: Intermediate (I)
C: Resistant (R)
b
when the MIC value is greater than the "R" breakpoint; MIC exceeds usual concentrations of the antibiotic so treatment will not likely eradicate the bacteria:

A: Susceptible (S)
B: Intermediate (I)
C: Resistant (R)
c
defined as ≥ 3 log10 CFU/mL reduction in growth (kill) at 24 hr of incubation

A: Bacteriostatic
B: Bactericidal
b
defined as < 3 log10 CFU/ml reduction in growth (kill) at 24 hr of incubation

A: Bacteriostatic
B: Bactericidal
a
a measure of pathogenicity or the likelihood of causing disease; properties that enhance the potential of the microorganism to cause disease:

A: Virulence
B: Resistance
a
the ability of a microorganism to stop an antimicrobial from working against it:

A: Virulence
B: Resistance
b
Pharmacokinetic properties:

A: ADME
B: AUC/MIC
a
Pharmacodynamic properties:

A: ADME
B: AUC/MIC
b
Streptococcus pyogenes:

A: Group A Strep
B: Group B Strep
C: Group C Strep
a
Streptococcus agalactiae:

A: Group A Strep
B: Group B Strep
C: Group C Strep
b
Streptococcus agalactiae:

A: alpha-hemolytic
B: beta-hemolytic
b
Streptococcus pyogenes:

A: alpha-hemolytic
B: beta-hemolytic
b
Streptococcus pneumoniae

A: alpha-hemolytic
B: beta-hemolytic
a
B-Lactams are:

A: bacteriocidal
B: bacteriostatic
a
Colonization is the presence of microorganisms which do not cause harm:

A: True
B: False
a
Defined as the lowest concentration of antibiotic that inhibits visible growth of an organism:

A: Minimum inhibitory concentration
a
If the bacteria goes from 9 to 2 in a 24 hour period, then it is __________ since it is more than log3:

A: Bacteriostatic
B: Bacteriocidal
b
S. Aureus will cause virulent, purulent infections:

A: True
B: False
a
All of the following are considered atypical bacteria except:

A: Legionella
B: Mycoplasma
C: Chlamydia
D: Moraxella
d
If someone develops a sore throat then that will be caused by:

A: S. Pyogenes
B: S. Agalactiae
C: S. Pneumoniae
a
What cephalosporin generation has MRSA resistance?

A: Ceftaroline
B: Cefazolin
C: Cephalexin
D: Cefepime
a
Erythromycin is a macrolide antibiotic with a glycosidic linkage that is stable in acidic pH and lactone bond that is stable in basic pH:

A: True
B: False
b
Amikacin has resistance to bacteria inactivation due to:

A: equatorial OH to an axial OH
B: Remove 3' OH in ring I
C: Insertion of steric group in ring II
c
If penicillin has a hydrophilic side chain (COOH) it will ________ in broad spectrum:

A: Increase
B: Decrease
a
Streptidine structure corresponds to:

A: Gentamicin
B: Tobramycin
C: Streptomycin
D: Amikacin
c
PCN and cephalosporin:

A: beta lactam
B: Lactobionate
C: Rings 1 and 3
a
Erythromycin parenteral:

A: beta lactam
B: Lactobionate
C: Rings 1 and 3
b
Which rings are susceptible to degradation:

A: beta lactam
B: Lactobionate
C: Rings 1 and 3
c
Aztreonam what's true about it?

A: Gram-ve action
B: Monobactam
C: Beta-lactamase resisntant
D: All the above
d
How to make erythromycin parenteral? You use _____ ester.

A: lactobionate
a
Tet(K) and Tet(AE) are ____ pumps that confer resistance to antibiotics:

A: efflux
a
A patient has developed a new pneumonia infection, and has been in a ventilator for 4 days. Samples were sent to the lab and his it was identified as gram negative bacilli lac - the bacteria can be identified as:

A: H. Influenza
B: P. aeroginosa
C: K. Pnemoniae
b
A patient presents to the outpatient clinic with a skin infection, erythematous, warm, purulent. What organism could cause this?

A. S. Aureus
B. P. Pneumonia
C. Strep. Pyogenes
a
What MLSB resistance is seen in S. Aureus:

A: Clindamycin
B: Azithromycin/Erythromycin
a,b
A patient has an infection but has used amoxicillin and has an adverse reaction to it. What can you give him?

A: Azithromycin
B: Pen V
C: Ampicillin
D: Piperacillin
a
Transpeptidation is when NAM and NAG bind to the serine in the PBP:

A: True
B: False
b
Which generation of cephalosporin is effective against MRSA:

A: 1st
B: 4th
C: 5th
D: 2nd
c
Transglycosylation when the NAM and NAG peptides bind to each other forming cross-links.

A: True
B: False
b
Which can be used against VRE?

A: Lipoglycopeptides
B: Oritavancin
a
By which mechanism is VRE resistant?

A: By replacing the D-ala-D-ala with D-ala-D-lactate
a
Binds to cell membrane in a Ca-dependent manner via insertion of its lipid tail:

A: vancomycin
B: Erythromycin
C: Daptomycin
D: Erythromycin
c
Inhibits PG synthesis by binding directly to the D-Ala D-Ala end of the peptide and forms a cap over the end of the chain blocking cross-linking:

A: vancomycin
B: Erythromycin
C: Daptomycin
D: Erythromycin
a
Penicillins work to inhibit the bacterial cell wall synthesis:

A: True
B: False
a
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