CMS: osteoporosis

reduction in the strength of bone that leads to increased risk of fractures
-bone density that falls 2.5 SD below the mean for a young normal individual
-common in elderly; women are at particularly

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Terms in this set (17)

reduction in the strength of bone that leads to increased risk of fractures
-bone density that falls 2.5 SD below the mean for a young normal individual
-common in elderly; women are at particularly

list some clinical features of osteoporosis

-loss of height, kyphosis, and secondary pain
-thoracic fractures associated restrictive lung disease, whereas lumbar fractures are sometimes associated with abdominal symptoms or nerve compression

what is the standard for measuring bone density?

dual energy X ray absorptiometry (DeXA)

osteoporosis tx

-lifestyle measures: adequate calcium and vit. D, exercise, smoking cessation, avoidance of alcohol use
-pharmacologic agents: bisphosphonates, estrogen, raloxifene

UTD recommends that postmenopausal women with established osteoporosis or fragility fracture be treated with pharamocologic agents, what is the initial tx?

bisphosphonates
ex: alendronate

rare complication of bisphosphonate tx mainly seen with high dose IV zoledronic acid or pamidronate administered in cancer pts

osteonecrosis of the jaw

what is the only drug available that induces bone formation?

teriparatide

*must be followed by antiresportive agent therapy to prevent rapid loss of newly formed bone

____ decreases the rate of bone reabsorption, but therapy should be carefully weighted in the context of increased risks of cardiovascular disease and breast cancer

____ is a selective estrogen receptor modulator, an alternative antiresorptive agent that can be used in lieu of estrogen
-has estrogenic effects on bone and lipids
-approved as agent for breast cancer prevention and tx of postmenopausal osteoporosis

defective mineralization of the organic matrix of bone results in what?