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ID Exam 1, Test 2 Practice Set

Terms in this set (44)

a
Tet(K) and Tet(AE) are examples of _______ pumps? (FIB)

a. Efflux
a,c,d
Which of these drug classes are active against atypical bacteria? (select all that apply)

a. Macrolides
b. Aminoglycosides
c. Tetracyclines
d. Fluoroquniolones
e. Oxazolidinones
c
Which of the following drug classes exhibits bactericidal activity?

a. Oxazolidinones
b. Tetracyclines
c. Aminoglycosides
d. Lincosamides
e. Macrolides
a
Match drug with its site of action? (Amantadine):

A. Ion-channel disruptor
B. Polymerase inhibitors
C. Neuraminidase inhibitors
c
Match drug with its site of action? (Peramivir):

A. Ion-channel disruptor
B. Polymerase inhibitors
C. Neuraminidase inhibitors
b
Acyclovir:

a. Competes with deoxyGTP for the viral RNA polymerase, resulting in reverse transcriptase
b. Is selective activated in infected cells
a
Where does linezolid bind?

a. 50S subunit of ribosome
b. Aminoacyl of tRNA
c. 30S subunit of ribosome
b
Which is a true about aminoglycosides?

a. Activity against gram (+) and anaerobes
b. Activity against gram (-) and aerobes
c. Activity against both gram (+) and gram (-)
d. Activity against gram (-) and anaerobes
b
Fluoroquinolones are active against RNA polymerase?

a. True
b. False
b
Rifamycins are active against DNA Topoisomerases?

a. True
b. False
b
Which fluoroquinolone has the least gram (+) activity?

a. Gentamicin
b. Ciprofloxacin
c. Moxifloxacin
b
What is the site of action of drugs that work against TB?

a. DNA polymerase
b. Mycolic acid
c. Reverse transcriptase
d. RNA polymerase
c
Which TB drug inhibits PABA?

a. Cycloserine
b. Isoniazid
c. PAS
d. Pyrazinamide
a
Does not require tyramine kinase?

a. Cidofovir
a,c
Resistance to sulfonamides is caused by? (Select all that apply)

a. Overproduction of PABA
b. Mutation of dihydrofolate reductase
c. Mutation of dihydropteroate synthase
d. Overproduction of dihydrofolic acid
c
Which medications are resistant to MLSB bacteria?

a. Dalfopristin
b. Chloramphenicol
c. Linezolid
d. Tetracycline
a
For tetracyclines: addition of (-N(CH3)2) at the 7th position increases antibacterial activity?

a. True
b. False
a
Epimerization of tetracycline occurs in acidic medium resulting in Epitetracycline?

a. True
b. False
a
Addition of a second dimethylamino to tetracyclines will result in increased activity?

a. True
b. False
a
Match drugs with mechanism of action:

(A) Sulfonamides; (A) PAS; (B) Trimethoprim
(A) Sulfonamides; (B) PAS; (B) Trimethoprim
(B) Sulfonamides; (A) PAS; (A) Trimethoprim
(B) Sulfonamides; (A) PAS; (B) Trimethoprim
c
Which of the following statements on quinolone structures is correct?

a. Compound A is active
b. Compound A and C are active
c. Compound A, B, and C all inactive
d. Compound B is active
c
Which enzyme catalyzes the cleavage of this compound?

a. Hemagglutinin
b. DNA polymerase
c. Neuraminidase
d. RNA polymerase
a
What are the administration forms of these anti-influenza agents? (Oseltamivir)

a. Oral
b. Inhalation
b
What are the administration forms of these anti-influenza agents? (Zanamivir)

a. Oral
b. Inhalation
a
Oseltamivir:

a. Is an ethyl ester prodrug converted by esterase in GIT
c
Which of the following is true regarding the half-life of Rifampin and Rifampentine?

a. Rifampin has a longer t1/2 than Rifampentine
b. Rifampin and Rifampentine have equal t1/2
c. Rifampentine has a longer t1/2 than Rifampin
d
Isoniazid:
I. Is a prodrug
II. Metabolized by KatG
III. Vitamin B6 is commonly co-administered

a. I only
b. I and II
c. II and III
d. I, II, and III
a
What drug does this structure represent?

a. Ethambutol
a
Which enzyme activates INH?

a. Catalase Peroxidase
a
Acyclovir is poorly water soluble and has poor oral bioavailability ....valacyclovir has greater bioavailability than acyclovir?

a. True
b. False
a
Which sulfanilamide metabolite is responsible for crystal urea?

a. Acetyl-transferase
b. Sulfone
c. Sulfa-Benzene
a
Based on the SAR of sulfonamides?

a. R4 must be a H
b
Which moiety is initially metabolized?

a. Metabolism of Bromo
b. N-demethylation
c. Hydroxylation of 2 rings
c
Which drug is semisynthetic and avoids efflux resistance?

a. Clindamycin
b. Acyclovir
c. Tigecycline
d. Linezolid
a
What is the active form of Chloramphenicol?

a. D-threo
b
Peramivir acts against which enzyme?

a. Acetyl-transferase
b. Sialidase
c. DNA polymerase
d. Reverse transcriptase
d
What is the mechanism of action of Tetracyclines?

a. Irreversible binding to the 30s subunit of the bacterial ribosome thereby producing a bactericidal effect.
b. Irreversible binding to the 30s subunit of the bacterial ribosome thereby producing a bacteriostatic effect.
c. Reversible binding to the 30s subunit of the bacterial ribosome thereby producing a bactericidal effect.
d. Reversible binding to the 30s subunit of the bacterial ribosome thereby producing a bacteriostatic effect.
A,b,d,e
Which of the following are cell wall active antibiotics?

a. Telavancin
b. Cycloserine
c. Doxycycline
d. Bacitracin
e. Aztreonam
f. Polymyxin B
b
Which functional group is thought to be chiefly responsible for the toxicity of chloramphenicol?

a. A secondary alcohol
b. An aromatic nitro group
c. An alkyl chloride
d. A primary alcohol
d
What cell structure is targeted by drugs such as the macrocodes, tetracyclines, and ahminoglycosides?

a. Cell wall
b. Cell membrane
c. Nucleus
d. Ribosomes
a
Saquinavir structure is shown. Match moiety B with its binding site.

a. S1
b. S2
c. S3
d. S1'
d
Drug class of nevirapine?

a. Nucleoside Reverse Transcriptase Inhibitors (NRTI)
b. Protease inhibitors
c. Integrase Inhibitors
d. Non-Nucleoside Reverse Transcriptase inhibitors (NNRTI)
c
Prevents the formation of covalent bonds between host and viral DNA through a
process known as stand transfer?

a. Saquinavir
b. Ritonavir
c. Raltegravir
d. Peramivir
b
Drug binds to gp41 viral glycoprotein?

a. Maraviroc
b. Enfuvirtide
c. Ritonavir
d. Saquinavir
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