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AP BIO Chapter 4
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Terms in this set (31)
Glycogen synthetase kinase 3 beta is a protein kinase that has been implicated in many types of cancer. Depending on the cell type, the gene for glycogen synthetase kinase 3 beta (GSK3β) can act either as an oncogene or as a tumor suppressor.
Which of the following best predicts how GSK3β mutations can lead to the development of cancer?
Cells with inactive GSK3βGSK3β fail to trigger apoptosis.
Cancer cells behave differently than normal body cells. For example, they ignore signals that tell them to stop dividing.
Which of the following conditions will most likely cause a normal body cell to become a cancer cell?
The environment contains mutagens that induce mutations that affect cell-cycle regulator proteins.
Researchers studying cell cycle regulation in budding yeast have observed that a mutation in the CDC15 gene causes cell cycle arrest in telophase when the yeast cells are incubated at an elevated temperature. Which of the following statements best predicts the effect of the cell cycle arrest on proliferating yeast cells?
The yeast cells will replicate their chromosomes but will fail to complete cytokinesis.
Vertebrate immune responses involve communication over short and long distances. Which of the following statements best helps explain how cell surface proteins, such as MHC proteins and T cell receptors, mediate cell communication over short distances?
The proteins interact directly with proteins on the surfaces of other cells.
Notch is a receptor protein displayed on the surface of certain cells in developing fruit fly embryos. Notch's ligand is a membrane-bound protein called Delta that is displayed on the surface of adjacent cells. When Notch is activated by its ligand, the intracellular tail of the Notch protein becomes separated from the rest of the protein. This allows the intracellular tail to move to the cell's nucleus and alter the expression of specific genes.
Which of the following statements best explains Delta's role in regulating cell communication through the Notch signaling pathway?
Delta restricts cell communication to short distances within a developing embryo.
In flowering plants, plasmodesmata are narrow channels through cell walls that connect the cytoplasms of adjacent cells. An explanation of how plant cells communicate across cell walls will most likely refer to the diffusion through plasmodesmata of which of the following?
Small, water-soluble molecules
The epinephrine signaling pathway plays a role in regulating glucose homeostasis in muscle cells. The signaling pathway is activated by the binding of epinephrine to the beta-2 adrenergic receptor. A simplified model of the epinephrine signaling pathway is represented in Figure 1.
Cyclic AMP phosphodiesterase is an enzyme that catalyzes the conversion of cyclic AMP to a different molecule. Which of the following best predicts the effect of inhibiting cyclic AMP phosphodiesterase in a muscle cell stimulated by epinephrine?
Phosphorylase kinase will remain active because protein kinase A will no longer be deactivated.
Air is less dense at very high elevations, so less oxygen is available than in the denser air at sea level. Based on the model in Figure 1, if a person travels from sea level to a high elevation location, which of the following correctly predicts the response to the decreased blood oxygen level?
More erythropoietin will be secreted from the kidneys, increasing production of erythrocytes.
The coagulation cascade controls blood clot formation in response to blood vessel injury. Thrombin is an enzyme that plays a key role in regulating the coagulation cascade. A simplified model of thrombin's role in regulating the coagulation cascade is represented in Figure 1.
Argatroban is a competitive inhibitor of thrombin. Which of the following effects on the coagulation cascade is most likely to result from inhibiting thrombin activity with argatroban?
The rate of fibrin formation will decrease.
The epinephrine signaling pathway plays a role in regulating glucose homeostasis in muscle cells. The signaling pathway is activated by the binding of epinephrine to the beta-2 adrenergic receptor. A simplified model of the epinephrine signaling pathway is represented in Figure 1.
Which of the following outcomes will most likely result from the irreversible binding of GDP to the G protein?
The intracellular concentration of glycogen will increase.
Glucocorticoids are steroid hormones that control cellular responses through several different signaling pathways. One of the signaling pathways involves the glucocorticoid receptor, an intracellular protein that is activated by binding to a glucocorticoid molecule. A simplified model of the glucocorticoid receptor signaling pathway is represented in Figure 1.
Which of the following statements best predicts the effect of a mutation that results in a loss of the glucocorticoid receptor's ligand binding function?
The glucocorticoid receptor will remain associated with the accessory proteins.
Figure 1 shows a model of a signal transduction cascade, initiated by the binding of a ligand to the transmembrane receptor protein A.
A DNA mutation changes the shape of the extracellular domain of transmembrane receptor protein A produced by the cell. Which of the following predictions is the most likely consequence of the mutation?
The molecule that normally binds to protein AA will no longer attach, deactivating the cellular response.
The epinephrine signaling pathway plays a role in regulating glucose homeostasis in muscle cells. The signaling pathway is activated by the binding of epinephrine to the beta-2 adrenergic receptor. A simplified model of the epinephrine signaling pathway is represented in Figure 1.
Based on Figure 1, which of the following statements best describes the epinephrine signaling pathway?
In involves enzymes activating other enzymes.
The epinephrine signaling pathway plays a role in regulating glucose homeostasis in muscle cells. The signaling pathway is activated by the binding of epinephrine to the beta-2 adrenergic receptor. A simplified model of the epinephrine signaling pathway is represented in Figure 1.
Which of the following statements best describes the role of adenylyl cyclase in the epinephrine signaling pathway?
It accelerates the production of a second messenger.
In a certain signal transduction pathway, the binding of an extracellular molecule to a cell-surface protein results in a rapid increase in the concentration of cyclic AMPAMP inside the cell. The cyclic AMPAMP binds to and activates cytosolic enzymes that then activate other enzymes in the cell.
Which of the following statements best describes the role of cyclic AMPAMP in the signal transduction pathway?
It acts as a second messenger that helps relay and amplify the signal within the cell.
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