• Ferrous Sulfate and Ferrous Gluconate
• MOA: Provides elemental iron essential to hemoglobin formation
• Dose: 50-100 mg elementall* iron PO TID
325 mg PO TID of salt form
• SE: Nausea, constipationn*, GI pain, vomiting, diarrhea, black stool, anorexia
• Intxns: Calcium, antacids, PPIss*, levodopa, fluoroquinolones, Vit E - dec absorption and effectiveness of iron
• Food intxns: cheese, coffee, milk, yogurt, whole grain breads, eggs
• Vitamin C increases iron absorption • Watch for ADRs:
-Heartburn, nausea, cramps, diarrhea, strong metallic taste
-Delayed rxns include myalgia, fatigue, arthralgia, fever, anaphylactoid
• Watch for drug intxns
-Iron decreases levothyroxine effects (separate by 4 hours)
-Any drug that changes gastric pH (antacids, PI, H2 blocker) or coffee, tea, fiber/bran reduces absorption
-Iron decreases absorption of TCN, PCN, quinolones
• Watch for contraindications
-Hemochromatosis, hemosiderosis, PUD, regional enteritis, or ulcerative colitis, repeated blood transfusions • Available as tablets, injection,,* ER tabs, SL tabs, Nasal spray, capsules
• Given parenterally when pts can't absorb oral (e.g. pernicious anemia)
• ADRs: Hypokalemia - w/ heavy dosing due to shift of intracellular K
Peripheral thrombosis
itching, swelling, urticaria
GI symptoms
Pain at injection site, hypersensitivity rxns
HA, anxiety • MOA: Inhibits Vit K dependent activation of clotting factors II, VII, IX, X formed in liver
Indications: Afib, prophylactic or tx of DVT/PE
Dose: Initially 2-5 mg PO or IV daily x 2-4 days, Then PT/INR guide dosage. Maintenance dose is usually 2-10 mg QD
SE: Fever, diarrhea, hemorrhage, hepatitis, rash, HA, N&V, hematuria, jaundice, dermatitis, urticaria, necrosis, alopecia
BBW: can cause major or fatal bleeding. More likely to occur at beginning of therapy and w/ higher doses • MOA: Inhibits coagulation factor Xa
• SE: bleeding, bruising, confusion, nausea, syncope
• Interactions: amiodarone, rifampin, aniplatelet meds, carbamazepine, phenytoin, azole antifungals, diltiazem, clarithromycin, erythromycin
• Reversal: stop dosing
• Avoid if creatine >2.0 (use UFH instead) MOA: inhibits coagulation factor Xa*
Dose: 20 mg QD
SE: bleeding bruising, pain in extremities and MSK, syncope
Interactions: rifampin, amiodarone, antiplatelet meds, carbamazepine, phenytoin, azole antifungals, diltiazem, clarithromycin, erythromycin
Reversal: stop dosing
Avoid if creatinine >2 (use UFH instead) MOA: inhibits factor IIa, thrombin, and thrombin induced platelet aggregation
Dose: 150mg BID, adjust for renal function
SE: bleeding/bruising, joint pain, fatigue, GI, peripheral edema
Interactions: Amiodarone, antiplatelet meds, azole antifungals, diltiazem, rifampin, clarithromycin
Reversal: Idarucizumab (Praxbind) • NSAID, antipyretic, anti-inflammaotory, antiplatelet
• MOA: Irreversiblyy* inhibits COX-1
• Dose: 81 mg PO QD
• SE: Tinnitus, N&V, GI bleed, prolonged bleeding time, bruising,,* thrombocytopenia, angioedema, Reye's syndrome • MOA: Increases adenosine, a coronary vasodilator and platelet aggregation inhibitor
• ADRs: dizziness, hypotension, nausea, HA, flushing
• Interactions: Adenosine, cholinesterase inhibitors, heparin, theophylline, garlic, dong quad, horse chestnut, red clover
• Metabolism: By liver, 1/2 life is 10-12 hrs • Synthetic analogue of ADH, available SC, IV, nasal, and oral
• MOA: ADH analogue
•Severe ADRs: Anaphylaxis, respiratory arrest, hyponatremia, water intoxication, seizures, thrombosis
• Common: flushing, HA, rhinitis, N&V, abd pain
Useful in most pts with type 1 vWD; variable in type 2; useless in type 3