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Terms in this set (19)
What are anti-metabolites?
Drugs that block or subvert the metabolic pathways involved in DNA synthesis
_________is a pyrimidine analogue that produces a fraudulent nucleotide and inhibits the enzyme ______________
What type of drug is methotrexate and what is its MOA
Folate antagonist- inhibits dihydrofolate reductase
What are cytotoxic drugs?
Chemotherapy drugs that bind directly to or act at DNA
What is the structure of Cisplatin and how does it work?
Central platinum with two Cl and two NH3
Binds to DNA via the Cl and inhibits replication and transcription
What type of DNA crosslinks is Cisplatin capable of?
Intrastrand - binds to the same strand
Interstrand- binds to both DNA strands
___________is a nitrogen mustard that forms covalent bonds with two nucleotides:______ and_______
Guanine and Adenosine
This drug is a topoisomerase inhibitor which prevents________ of DNA for replication
There are plant derivative drugs that inhibit stages in microtubule assembly and de-assembly. Which one inhibits a) Polymerisation and b) De-polymerisation
A) Vinca alkaloids e.g. Vincristine
B) Taxane e.g. Paclitaxel
Vincristine and Paclitaxel are examples of ______ phase (of cell cycle) drugs
M phase - mitosis requires microtubules
Why is a patient on chemotherapy at risk of hyperkalaemia
Cell death can cause potassium release from tumour and surrounding cells
Purine and pyrimidine analogs and folate inhibitors are all drugs which affect the _______ phase of the cell cycle
S phase- DNA replication
Hyperuricaemia can result from chemotherapy- what symptom can this cause and how is it treated
What is tumour lysis syndrome?
As the tumour is killed, the cell debris and nitrogenous waste causes hyperuricaemia and hyperkalaemia
Ondastrenon is a type of ___________ used to treat __________ (a side effect of chemo)
5HT3 antagonist- nausea and vomiting
Glucocorticoids can treat acute and malignant lymphomas- what is their mechanism of action?
Suppression of mitosis by binding the intracellular receptors, dimerising and altering transcription of proteins needed for the cell cycle
This is an oral glucocorticoid that can treat lymphoma
Raloxifene is an oestrogen receptor antagonist in the breasts- what feature does it have that allows its use for other conditions?
It is a partial agonist in bone leading to its use as a treatment of osteoporosis
Which breast cancer drug can decrease the risk of endometrial cancer and why?
Raloxifene- it is an an oestrogen antagonist at the endometrium where oestrogen can increase hyperplasia
THIS SET IS OFTEN IN FOLDERS WITH...
Erythropoiesis and globin chain abnormalities
Leukaemia and lymphoma
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