Upgrade to remove ads
Terms in this set (112)
What are two parts of epidermal hyperplasia?
What is hyperkeratosis?
increase in thickness of epidermis by proliferation of viable keratinocytes, excluding cornified layer, thickening of the stratum corneum with a qualitative abnormality of keratin
What is acanthosis?
increased thickness of the stratum spinosum, thus the epidermis, due to hyperplasia (acanthosis) or hypertrophy (pseudoacanthosis)
What are the two types of hyperkeratosis?
orthokeratotic - non-nucleated cells present
Parakeratotic - nucleated cells present
What is the cutaneous benign tumor that characterizes the mucocutaneous junctions, the skin, the GI which is characterized by fronds with stroma and also has viral origin
Equine sarcoid caused by bovine papillomavirus
What is acantholysis?
detachment of epidermal cells, particularly those of the stratum spinosum from one another due to breakdown of intercellular bridges, resulting in the formation of intraepidermal vesicles
what are the detached cells within the vesicle called?
acanthocytes or acantholytic cells
What is an apoptotic body?
round eosinophilic cellular extrusion formed during the apoptosis of the epidermal epithelial cells
What can the apoptotic body be called? (?)
- Civatte body
- colloid body
- hyaline body
What is acantholysis a sign of?
- pemphigus foliaceus (common)
- pemphigus vulgaris (rare)
What is spongiosis?
widening of intercellular spaces due to intercellular epidermal edema
What is hydropic degeneration?
intracellular edema with vacuolar alteration
What is ballooning degeneration?
specific degeneration change in epidermal cells characterized by swollen, pale eosinophilic cytoplasm with intracellular edema and without vacuolation
what is a pustule?
circumscribed epidermal (sometimes dermal) accumulation of purulent exudate
(a pus-filled vesicle)
What is pyoderma?
What is impetigo?
superficial pyogenic infection with nonfollicular pustules and friable, adherent crust
What cells characterize a pustule?
What disease targets Desmoglein 1?
What disease targets Desmoglein 3?
What does a pemphigus pustule contain?
What are the possible pathologic changes of dermal collagen?
- flame figures
What are the common diseases that cause pathologic changes of dermal collagen?
- eosinophilic collagenolytic granuloma complex
- calcinosis cutis
vertical streaking in lick granuloma/friction dermatitis
- collagen lysis is commonly seen in mast cell tumors
What is mucinous degeneration also known as?
- myxoid degeneration
- mucinosis myxedema
What is mucinous degeneration?
excessive deposition of mucin (GAG) which can look like non-pitting edema either focally of diffusely
What can cause focal form of mucinous degeneration?
associated with inflammatory, neoplastic, and developmental dermatosis
what can cause the diffuse form of mucinous degeneration?
- lupus erythematosus
- cutaneous mucinosis
What is the breed that frequently presents an acceptable level of diffuse mucinous skin?
Describe black hair follicular dysplasia
- large and variably sized and shaped melanin pigment granules are present in hair shafts and hair matrix of cells
- clumping of melanocytes in hair shaft
Name the breeds with black hair follicular dysplasia
- Portuguese water dog
- Irish water spaniel
- curly coated retriever
What is panniculitis?
inflammation of fat
What causes the majority of panniculitis?
sterile or idiopathic
Name the breeds that get sterile and idiopathic panniculitis.
- Miniature poodle
What are signs of ACUTE dermatitis?
Are vesicles a sign of acute dermatitis?
Name the lesions that are found in ACUTE dermatitis.
What are the lesions are chronic dermatitis?
- mild erythema
- pigmentary disturbances
What is called when inflammatory cells are around blood vessels?
What is interface dermatitis?
when the dermoepidermal junction is obscured by hydropic vacuolar degeneration of basal cells and/or lichenoid cellular infiltrates
When is the hydropic interface dermatitis seen?
- drug eruptions
- lupus erythematosus
- toxic epidermal necrolysis
- graft vs host reactions
When is the lichenoid interface dermatitis seen?
- drug eruptions
- lupus erythematosus
- vogtkoyanagi-harada- like syndrome
What is mycosis fungoides (cutaneous T-cell lymphosarcoma) is often characterized by?
Lichenoid lymphocytic accumulation
What is mycosis fungoides?
neoplastic disease of skin characterized by T cells and forms pustules of lymphocytes called Pautrier microabscesses
What it is called when melanin accumulates down into the dermis that is a feature of autoimmune diseases?
What can cause fibrinoid necrosis?
- most often due to ag-ab complexes
- may also be seen in mast cell tumors
what is fibrinoid necrosis?
necrosis of the vessels wall characterized by homogeneous eosinophilia
(no fibrin, just fibrinoid)
When is neutrophilic vasculitis seen?
- connective tissue disorders (LE, dermatomyositis)
- hypersensitivity reactions
- Equine purpura hemorrhagica
What may result in ischemic necrosis of the skin?
What is the presence of fibrin called?
What does fibrinoid mean?
Looks like fibrin
Nodular dermatitis is often caused by
What are the common etiologies of nodular dermatitis?
- foreign body
- reactive histiocytosis
- nodular panniculitis
What are collagenolytic granuloma complexes often characterized by?
nodules or plaques
T or F: True diffuse dermatitis is rare.
Which inflammatory cell characterizes granulomatous dermatitis?
Which inflammatory cell characterizes suppurative dermatitis?
What are the two inflammatory cells that simultaneously present in a pyogranulamatous dermatitis?
neutrophils and macrophages
When is there fusion of macrophages?
What are 3 species that have more frequently collagenolytic eosinophilic granulomas?
Describe Atypical mycobacteriosis
pyogranulomatous inflammation surrounding a vacuole containing bacteria
(use acid fast stain to identify)
What is the genus of the bacterium that causes cutaneous tuberculosis?
Which agent causes leprosy?
Which cell characterizes mycobacterial infection?
What are the two stains that is used for acid fast bacteria?
- Ziehl - Neelsen (most common)
- Fite - Faraco (stains all mycobacteria)
What is perifolliculitis?
inflammation around hair follicle
What is folliculitis?
inflammation of a hair follicle
What is furunculosis?
Describe the progression of folliculitis.
- perivascular near follicles
- mural folliculitis
- luminal folliculitis
What are the common causes of folliculitis, perifolliculitis, and furunculosis?
Name an agent able to cause folliculitis, perifolliculitis, and furunculitis.
Seeing periocular dermatitis should make you think of
what are two examples of dermatophytes of animal skin?
- trychophyton verrucosum (cow)
- microsporum canis (dog)
What is sebaceous adenitis?
inflammation concentrated in and around sebaceous glands
How is atrophic dermatosis characterized?
varying degrees of epithelial and connective tissue atrophy
Name the causes of atrophic dermatosis.
- endocrine dermatoses
- nutritional dermatoses
- developmental dermatoses
-telogen effluvium (temporary hair loss)
- Postclipping follicular arrest
what is the most commonly diagnosed endocrine disease of the dog and is caused by either lymphocytic thyroiditis or idiopathic thyroid atrophy?
What is the primary inflammatory cell targeting thyroid cells causing hypothyroidism?
Functional sertoli cell tumors leading to hyperestrogenism are usually associated with
What is the difference between calcinosis cutis and calcinosis circumscripta?
cutis is mineralization; calcium deposition of the skin(broad) while circumscripta is in same but in circumscribed areas
What breeds is alopecia X seen/diagnosed in?
- chow chow
What is one histological feature that characterizes alopecia X?
What could periocular crusting indicate?
- zinc responsive dermatosis
What does congenital hypotrichosis cause?
partial to complete loss of hair
when might hypertrichosis occur?
- pituitary tumors in old horses
- chronic FMD infection in cattle
What are two tumors predisposed by sun exposure?
- squamous cell carcinoma
Describe superficial necrolytic dermatitis.
necrotizing skin disorder of dogs most often associated with severe hepatopathy, pancreatic lesions and diabetes mellitus
What are the three layers of necrolytic dermatitis?
- red- hyperparakeratosis
- white- edema
- blue- hyperplastic basal layer of epidermis
What happens to the amino acids with necrolytic dermatitis?
decreased from impaired amino acid metabolism
Describe Type I, II, and III hypersensitivity reactions.
immediate, antibody-mediated reactions
Type I hypersensitivity reactions
Type II hypersensitivity reactions
Type III hypersensitivity reactions
(serum sickness and glomerulonephritis)
Which is the most common ruminant that has pemphigus foliaceous or autoimmune dermatoses?
What is pemphigus?
Group of autoimmune skin diseases grossly characterized by pustules, vesicles, bullae, erosions, and ulcers, histologically by acantholysis and immunologically by the autoantibodies against antigenic molecules of keratinocyte desmosomes. (deposited antibodies are mainly IgG)
Which pemphigus is more common?
What is in the pustule of pemphigus?
What is the most common dermatosis we will see in our career?
What causes triggers pemphigus?
- trigger is unknown
- antibiotics precipitate
- UV light exacerbates
Lesions such as erosions, depigmentation, and crusts present in the foot pad could be which things?
- Necrolytic dermatitis
- autoimmune disease (pemphigus)
What is the disease characterized by floating acanthocytes that form pustules?
How is Pemphigus vulgaris characterized?
uclers - goes deeper than foliaceous
What is systemic lupus erythematous?
multisystemic autoimmune disease characterized by fever of unknown origin, weight loss, polyarthritis, hemolytic anemia, thrombocytopenia, neutropenia, stomatitis, glomerulonephritis, and dermatitis
How often is the cutaneous presentation seen in SLE?
What is a way to test for SLE?
Where does the main tissue damage come from in SLE?
ag-ab complex deposits
What are the breeds associated with SLE?
- shetland sheepdog
- german shepard
-siamese and other pure bred cats
Name the multisystemic autoimmune disease characterized by fever of unknown origin, weight loss, polyarthritis, hemolytic anemia, thrombocytopenia, neutropenia, stomatitis, glomerulonephritis, and dermatitis?
Systemic Lupus Erythema
What is cutaneous Lupus Erythematosus?
lesions are limited to the skin, no systemic signs
What are the cutaneous LE subgroups?
- vesicular CLE (ulcerative dermatosis) of shetland sheepdog and collie
- exfoliative CLE (Lupoid dermatosis) of the german shorthaired pointer
chronic lesions of hair loss, hyperpigmentation, and scarring are present in the skin around the eye and on lateral side of face, also erosion, atrophy of dermis, adnexa, and muscle atrophy
What is the characteristic histologic lesion of erythema multiforme?
apoptosis, sometimes lymphocytes surround the apoptotic keratinocytes
What is satellitosis?
when lymphocytes surround the apoptotic keratinocytes
What are the suggestive changes in erythema multiforme?
apoptosis and sarelitosis
Recommended textbook explanations
Lisa A. Urry, Michael L. Cain, Peter V Minorsky, Steven A. Wasserman
Biocalculus: Calculus for the Life Sciences
Campbell Biology (AP Edition)
Cain, Jackson, Minorsky, Reece, Urry, Wasserman
Biocalculus: Calculus, Probability, and Statistics for the Life Sciences
Sets found in the same folder
Sys Path- GI Day 1
VMED 5242 Neuropathology Introduction
Sys Path - GI Day 2
Other sets by this creator
Therio Exam 2
Therio Exam 2
Dog + Cat Medicine Exam 1
Equine Med + Surg Exam 1 (Lectures 1-12)
Other Quizlet sets
CIT203 Module 1-2 REVIEW
Advanced Math Chapter 4
Lung cancer (2)