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perio 2 e1 ch 22 book
Terms in this set (36)
etiology of most cases is lichen planus, cicatricial pemphigoid, or pemphigus vulgaris
intense erythema, desquamation, and ulceration gingival response associated with a number of conditions
t/f desquamative gingivitis was not a specific disease entity but a gingival response associated with a variety of conditions.
t/f Desquamative gingivitis is a clinical term and not a diagnosis.
blister formation or peeling of skin or mucosa when horizontal tangential pressure is applied to the skin or mucosa in patients with vesiculobullous disorders.
hematoxylin and eosin
? immunofluorescence unfixed frozen sections are incubated with a variety of fluorescein-labeled, antihuman serum (i.e., anti-IgG, anti-IgA, anti-IgM, antifibrin, and anti-C3)
? immunofluorescenceunfixed frozen sections of oral or esophageal mucosa from an animal such as a monkey are first incubated with the patient's serum to enable attachment of serum antibodies to the mucosal tissue. The tissue is then incubated with fluorescein-labeled antihuman serum
Immunofluorescence tests are ? positive if a fluorescent signal is observed in the epithelium, its associated basement membrane, or the underlying connective tissue
t/f Pemphigus vulgaris is an example of a condition that, after diagnosis by the dentist, requires immediate referral to a dermatologis
t/f squamous cell carcinoma can mimic desquamative gingivitis
an inflammatory mucocutaneous disorder that can involve the mucosal surfaces (e.g., oral cavity, genital tract, other mucosae) and the skin, including the scalp and the nails
t/f Most patients with oral lichen planus are middle-aged or older women; the disorder occurs with a 2 : 1 ratio of women to men
t/f Children are rarely affected
t/f the most common form of lichen planus is reticular and erosive subtypes
lichen planus can occur as one of the four distinctive patterns
erosive or ulcerative
vesicular or bullous lesions
The raised, white lesions can manifest as groups of individual papules, linear or reticular lesions, or plaquelike configurations
The extensive erythematous areas with a patchy distribution can manifest as focal or diffuse hemorrhagic areas. The lesions are exacerbated by slight trauma (e.g., toothbrushing)
erosive or ulcerative lesions
The raised, fluid-filled lesions are uncommon and short lived on the gingiva, quickly rupturing and leaving ulcerations.
vesicular or bullous lesions
Atrophy of the gingival tissues with ensuing epithelial thinning results in erythema that is confined to the gingiva
linchen planus and pemphigoid count for about ?% of chronic DG
Microscopically, three main features characterize oral ?: (1) hyperkeratosis or parakeratosis, (2) hydropic degeneration of the basal layer, and (3) a dense, bandlike infiltrate, consisting primarily of T lymphocytes, in the lamina propria
oral cancer emerges in up to ?% of patients with oral lichen planus
several cutaneous, immune-mediated, subepithelial bullous diseases that are characterized by a separation of the basement membrane zone, including bullous pemphigoid, MMP, and pemphigoid (herpes) gestationis
nonscarring and mainly affects the skin.vs when scarring occurs, and the disease is mainly confined to mucous membranes types of pemphigoid
bullous vs cicatricial
chronic, autoimmune, subepidermal bullous disease with tense cutaneous bullae that rupture and become flaccid
the primary treatment is a moderate dose of systemic prednisone
is a chronic vesiculobullous autoimmune disorder of unknown cause that predominantly affects women during the fifth decade of life. It has rarely been reported in young children
involves the oral cavity, the conjunctiva, and the mucosa of the nose, vagina, rectum, esophagus, and urethra
cicatricial pemphigoid (MMP)
t/f Symblepharon (i.e., scarring resulting in adhesion of the eyelid to the eyeball) is a significant complication of MMP
potentially lethal chronic condition with a 10% mortality rate
group of autoimmune bullous disorders that produce cutaneous and mucous membranes blisters
immediate referral to a dermatologist or rheumatologist
involves the separation of the epithelial cells of the lower stratum spinosum, takes place.
Painful solitary small blisters and erosions with surrounding erythema occur mainly on the gingiva and the lateral border of the tongue.
chronic ulcerative stomatitis
chronic ulcerative stomatitis do not respond to corticosteroid treatment, but they are responsive to hydroxychloroquine t/f
-mucocutaneous disorder with a predilection for women
pruritic vesiculobullous rash
-plaques or crops with an annular manifestation surrounded by a peripheral rim of blisters affect the skin of the upper and lower trunk, the shoulders, the groin, and the lower limbs. The face and perineum may also be affected.
-painful ulcerations or erosions, and erosive gingivitis or cheilitis. The hard and soft palates are affected more often; the tonsillar pillars, buccal mucosa, tongue, and gingiva follow in frequency.
LAD (i.e., linear IgA dermatosis)
usually develops in young adults between the ages of 20 and 30 years, and it has a slight predilection for men.
cutaneous manifestation of celiac disease.
bilateral and symmetric pruritic papules or vesicles that are primarily restricted to the extensor surfaces of the extremities
severe disease with a 10 : 1 predilection for women compared with men
kidneys, heart, skin, and mucosa.
ulcerative or similar to those of lichen planus
two most common etiologic factors herpes simplex infection and drug reactions
multiple, large, shallow, painful ulcers with an erythematous border.
so painful that chewing and swallowing are impaired
Hemorrhagic crusting of the vermilion border of the lips may occur, which is helpful for arriving at a clinical diagnosis
Eruptions in the oral cavity that result from sensitivity to drugs that have been taken orally or parenterally are called
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