Study sets, textbooks, questions
Upgrade to remove ads
Oxyhemoglobin dissociation Curve (APEX question 14) material
Terms in this set (15)
What are two ways to remember left shift and right shift? (Think mnemonic)
Look in apex and explain the curve in your own words
What are causes of right shift of the oxyhemoglobin dissociation curve?
1) increased PC02
2) increase 2-3 DPG
3) increase temperature
4) acidosis (increased hydrogen ion)
5) decreased pH
What are causes of left shift of the oxyhemoglobin dissociation curve?
1) decreased PCO2
2) decreased 2-3 DPG
4) decreased hydrogen=
5) increased pH
6)increased fetal hemoglobin
7)increased carbon monoxide
What is the P50? High P50 means curve shifted to the ______________ and low P50 means curve shifted to the ____________________.
The P50 is the PaO2 where hemoglobin is 50% saturated
A low P50 will reflect a left shift and a high P50 will reflect a right shift in the oxyhemoglobin dissociation curve
What PaO2 does maximum oxygen loading occur at? Can we improve O2 loading if the PaO2 is above 100mmHg? What occurs?
Maximum o2 loading occurs at a PaO2 of up to 100mmHg. A PaO2 above 100mmHg will not improve oxygen loading, it will increase the amount of oxygen that is dissolved in the plasma
What does metabolic rate have to do with shifting the oxyhemoglobin dissociation curve? Will it shift the curve left or right? Why? What are things that should shift the curve this way?
Metabolic rate is a big factor in shifting the curve. Tissues that have a higher metabolic rate will consume more oxygen and will produce more CO2, hydrogen ion and heat. This will cause a right shift in the curve (rise in temperature, increase in 2-3 DPG, CO2 and hydrogen ion)
What is the Bohr effect? What two things are specific to the Bohr effect?
CO2 and Hydrogen ion
These two molecules will cause a conformational change in the hemoglobin molecule which will facilitate it to release oxygen
CO2 and hydrogen will cause hemoglobin to release oxygen
What are things that would cause a left shift again?
You should know this, some hemoglobinopatheis can cause a left shift
When is 2-3 DPG produced? What pathway is this called
2-3 DPG is produced during RBC glycolysis
Called the Rapoport Luebering pathway
Which way will an increase in 2-3 DPG shift the oxyhemoglobin dissociation curve?
This will maintain the curve in a slightly right shifted position
Will hypoxia increase or decrease 2-3 DPG production? What will this facilitate?
Hypoxia will increase 2-3 DPG production and will facilitate offloading of oxygen
For a normal hemoglobin, what is the partial pressure of oxygen for the P50?
What occurs with 2-3 DPG in banked blood? Which way would the curve move?
The concentration of 2-3 DPG would decrease and this would shift the curve to the left and will reduce the amount of O2 available at the tissue level
Will 2-3 DPG respond to Fetal Hemoglobin? What is the P50?
HGB F will not respond to 2-3DPG hence the left shift in the curve
P50 would be 19mmHg
Sets found in the same folder
Oxygen Content, delivery and Consumption section A…
Cellular Energetics APEX (question 15) respiratory…
Carbon Dioxide Transport (question 16) APEX respir…
The Haldene Effect and CO2 Dissociation Curve APEX…
Other sets by this creator
Cardiac ECG information (12 leads, etc)
Other Quizlet sets
Human G&D Chapters 5& 6
Micro Lab Midterm
Intro to Business - Ch. 7