Fatty acid synthesis

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The tissues in which fatty acid synthesis occurs are -
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Terms in this set (14)
The tissues in which fatty acid synthesis occurs are -
Liver ( Main lipogenic organ)
Adipose Tissue
Lactating mammary glands
Brain
Kidney
True /False
Fatty acids are synthesized from acetyl CoA
True
True/False
Source of Reductive power for fatty acid synthesis is NADP
TRUE
True /False
Acetyl CoA carboxylase has allosteric site for citrate binding
true
True/False
Phosphorylation of acetylcoA carboxylase inhibits its activity
True
True/False
Insulin is a lipogenic hormone
true
True/False
Starvation and High fat and low carbohydrate diet leads to downregulation of acetyl CoA synthesis
True
True/False
Fatty acid elongation beyond 16 carbon requires another set of enzymes than fatty acid synthase complex
yes, Elongation of fatty acid occurs in ER and it requires another set of enzymes
Let us assume that you are synthesizing 20 carbon long chain fatty acid by a fatty acids synthase complex in laboratory. How many cycles, NADPH, Acetyl CoA ( for direct use) , Malonyl CoA and ATP are needed ?
Cycles- 9
NADPH = 9 X2 = 18
Acetyl CoA =1
Malonyl CoA= 9
ATP= 9
Let us assume that you are synthesizing 20 carbon long chain fatty acid by a fatty acids synthase complex in laboratory. Which carbons will be derived from Acetyl CoA?
Carbon atoms 19 , 20
For Elongation of 16 carbon palmitic acid into 28 Carbon long fatty acids, How many cycles, NADPH, Malonyl Coa, Acetyl coa ( direct) are needed.28-16= 12/2= 6 cycles NADPH= 6 X2 = 12 Malonyl CoA= 6 Acetyl CoA= 0true/False Desaturases require molecular oxygenTrue Desaturases require molecular oxygen, Cytochrome b5 & NADHTrue/FALSE The fed state is associated with induction of enzymes needed for fatty acid synthesisTrueTrue/False Human desaturases cannot introduce double bond beyond Carbon 9True