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Innate Immune system
Terms in this set (11)
What is the role of each cell type during innate immune responses? Natural killer cells
Kill cells infected with intracellular pathogens like viruses
What is the role of each cell type during innate immune responses? Neutrophils
Kill extracellular pathogens via phagocytosis
What is the role of each cell type during innate immune responses? Eosinophils
Involved in parasitic infections, release granules, alter hemostasis
What is the role of each cell type during innate immune responses? Basophils
Involved in allergic reactions, release granules, alter hemostasis
What is the role of each cell type during innate immune responses? Dendritic cell
antigen presenting to naive lymphocytes in lymph nodes
What is the role of each cell type during innate immune responses? Mast cells
Release histamine in allergic reactions
What is the role of each cell type during innate immune responses? Macrophages
kill extracellular pathogens via phagocytosis and release cytokines that mediate the inflammatory response
low neutrophils; elevated monocytes and eosinophils, elevated immunoglobins
Compare and contrast the role of the P-selectin & E-selectin's with ICAM-1& LFA-1during extravasation.
P-selectins are expressed on platelets and leukocytes vs E-selectins are expressed on endoethelial cells and help leukocytes comes to a rolling stop at the site of infection. Once stopped the integrin connection via ICAM-1 on endothelial cells and LFA-1 on leukocytes form a stronger connection and helps neutrophils extravasate into the infected/injured tissue.
Which chemokines are important for the movement of neutrophils versus monocytes to the site of an infection?
CCL2 for monocytes
CXCL8 for neutrophils
Order of complement pathway activation
alternative pathway --> lectin pathway --> classical pathway
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