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chapter 13 smartwork and bookwork
Terms in this set (44)
______ is the process by which a chemical kills disease producing microbes on inanimate surfaces
the effectiveness of a chemical agent is determined by
decimal reduction time
Standard autoclave conditions
121 C, 15 pounds of pressure, 20 minutes
an injectable drug solution filtered through 0.2 nm filter should be considered sterile
pasteurization conditions are designed to kill which of the following microbes from milk
food supplement that must have a long shelf life without refrigeration
chemical agent A with phenol coefficient of 10 is _______ effective at killing that chemical B with a phenol coefficient of 50
which is an effective way to sterilize plasticware such as a petri dish
irradiation and ethylene oxide gas
what is useful as a disinfectant but not as an antiseptic
theres blood on the medical examination table. which disinfectant is best for decontamination
tube 1 has the highest concentration of drug and tube 6 has the lowest. growth occurs in 5 and 6 no growth is seen in 1-4.
1. which tube represents MIC
2. which tube represents MBC
1. tube 4
2. cant say. not enough info
which of the following antibiotic classes and host targets are matched correctly
amino-glycoside - 30S ribosome
a bacterial pathogen that produces the enzyme beta- lactamase will be resistant to which of the following antibiotics
the following antibiotics affect cell wall synthesis
_____ is a single bacterial system that can provide resistance to multipul classes of antibiotics simultaneously
a multidrug efflux pump
acts as a decoy for beta- lactamase
pump antibiotic out of cell
which of the following classes of antivirals are used to treat influenza
which of the following best explains selective toxicity of antiviral nucleoside analogs
viral polymerases are less selective than host polymerases
viral RNA synthesis
among the anti-fungal agents_______ interferes with ergosterol synthesis ________ inhibits DNA synthesis and ______ disrupts the mitotic spindle
a triazole or allylamine
a male patient complains of an itchy irritation in his genital region. your diagnosis is a superficial fungal infection which of the following drugs is the usual treatment for this disease
a female patient has a severe respiratory distress. she has a sever lung infection caused by histoplasma which drug would be most appropriate
Which of the following represent legitimate targets for antibacterial drugs?
Which of the following are likely to be "missed" when food is irradiated prior to sale? In other words, which of the following are likely to escape destruction and remain on the food sample?
vancomycin affects cell wall synthesis, the polymyxins disrupt the cell membrane, the sulfonamides block a key step in folic acid synthesis, quinolones interfere with DNA gyrase, rifampin inhibits transcription, erythromycin is a 50S ribosomal subunit inhibitor, and gentamicin is a 30S ribosomal subunit inhibitor.
As a baseline for measurement of the antimicrobial properties of chemical disinfectants, the coefficient test____________ compares the antimicrobial properties of the many chemical disinfectants to that of this important chemical, which was first introduced by Joseph Lister in 1867.
A germicide is applied to a surface. By definition, this chemical will most likely __________ that surface.
When an antibacterial agent is ________ , the application of the chemical does not kill bacterial cells; rather, it stops them from replicating.
When microbial growth medium is made, it is put into the autoclave to _____________the medium before organisms can be inoculated and grown into a pure culture.
Microbial growth slows down when the sample is (A)________ , but there is no microbial growth at all when the sample is (B) .__________
Refrigerated ; lyophilized
In terms of the range of affected microbes, which of the following agents will likely affect vegetative bacterial cells, mycobacteria, spores, fungi, and viruses?
Chlorine gas, bleach, and iodine tinctures are classified in which disinfectant grouping?
triclosan is a halogenated bisphenol. It is bactericidal at high concentration, but at low concentration, it is bacteriostatic because it inhibits biosynthesis of which of the following?
in the image of the Kirby-Bauer assay, drag the labels to the targets to identify a drug to which these bacteria are sensitive and a drug to which these bacteria are resistant.
The bacteria are not affected by the presence of oxacillin (OX), so they are resistant to this type of drug; there is no zone of inhibition around the OX disk, meaning that the drug is not negatively affecting their growth. However, a zone of inhibition is evident around the rifampicin (RA) disk, meaning that the bacteria are sensitive.
A (A) ________chemotherapeutic index correlates with a safer drug. This type of drug affects more (B)_________ cells.
higher ; prokaryotic
Which of the following antibiotics has the mechanism of action most similar to that of the aminoglycosides?
Selective toxicity for antiviral drugs is to achieve as compared to selective toxicity for antibacterial drugs.
Antiviral drugs that are classified as reverse transcriptase inhibitors are most effective against viruses that have________ as their genome.
Consider the graphical relationship between the MIC of an antibiotic against a particular pathogen and the serum concentration of that drug. Now imagine that structural changes to this antibiotic reduced the MIC down to 1 μg/ml. How often would this new medication need to be taken to control an infection by the respective pathogen?
twice a day
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