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Terms in this set (108)

Long Term:
-Inhaled corticosteroids: anti-inflammatory, decrease hyper-responsiveness, inhibit inflammatory cell migration and activation, block late reactions to allergen, decrease exacerbations (ex: beclomethasone, budesonide)
-Long acting beta agonists: relaxes smooth muscles in airway, duration of action at least 12 hours, used in combination with ICS(ex: salmeterol, famoterol)
-Leukotriene modifiers: decrease inflammation cascade, alternate choice for mild persistent asthma, used with ICS for moderate-to-severe asthma (ex: Montelukast, Zafirlukast)
-Mast cell inhibitors: interfere with chloride channels, stabilize mast cells, alternative for mild persistent(ex: cromolyn sodium, nedocromil)
-Anti-immunoglobulin E antibody: children ≥12 years old with sensitivity to dust mites, cockroaches, dogs, and cats; used in moderate-to-severe persistent asthma; anaphylaxis may occur
-Methylxanthines: relax smooth muscles in airway, continuous airway dilation (ex: PO theophylline, IV aminophylline, monitor serum levels)

Short Term:
-SABA: relaxes smooth muscles in the airway, increases water into mucus, promoting clearance, effects seen in 5-10 min. Drug of choice acute therapy, nebulizer, or metered dose inhaler (ex: albuterol, terbutaline, levalbuterol)
-Corticosteroids: decrease airway inflammation, enhance bronchodilation effects of SABA,use in moderate-to-severe persistent asthma with SABA(ex: methylprednisone, IV or PO)
-Anticholinergics: inhibit bronchoconstriction, decrease mucous production, used with SABA in acute exacerbation