Study sets, textbooks, questions
Upgrade to remove ads
Terms in this set (37)
time course of drug absorption, distribution, metabolism and excretion (ADME).
what the body does to the drug
relationship between drug concentration at site of action (e.g. receptor) and pharmacologic response.
what the drug does to the body
Drug ________ is the link between PK-PD
and provides the basis for rational drug dosing
The movement of drug from an extravascular site of administration across biological barriers into the systemic circulation
Drug properties, e.g. solubility & permeability
The transport of drug from one site to a different site within the body
Perfusion rate to tissues/organs
Drug properties, e.g. plasma protein binding and polarity
Enzymatic conversion of drugs to other chemical species (metabolites)
metabolism primary site
Metabolites are generally
More water soluble and excretable
Less active and toxic
Drug structure (functional groups)
Removal of drugs and metabolites from the body
Excretion factors excretion primary
Kidney function, urine pH ...
Drug properties, e.g. MW & polarity
excretion primary route
Other routes - biliary (fecal), pulmonary ...
metabolism + excretion
Quantitative analysis of the ADME processes
PK Modeling goals
Predict drug conc in the body over time
Predict pharmacological effects over time
Drug conc, where?
Typically plasma/serum drug conc (Cp)
Compartment models -
body as interconnected compartments
two- or three-compartment
Once distribution equilibrium is reached, the plasma drug conc (Cp) correlates ______ to the drug conc at other tissues
AUC (Area Under the Curve)
Reflects overall exposure
Used for bioavailability calculation
______ studies the quantitative relationship between drug concentration and its effect.
______ studies the time course of drug disposition after dose administration.
In the Prescribing Information of a drug product, which section describes the ADME behavior of the drug?
Co-administration of fluoxetine increases the plasma concentration of amitriptyline. This is a _________ drug interaction.
Co-administration of fluoxetine and tramadol leads to serotonin overload. This is a _________ drug interaction.
Which of the following is a systemically acting drug product?
a. Metformin tablet for type-2 diabetes
b. Albuterol inhaler for asthma
c. Salicylic acid solution for acne
d. Timolol eye drop for glaucoma
e. PEG 3350 powder for constipation
What is the main purpose of PK modeling?
a. To increase the drug bioavailability
b. To improve the drug-receptor binding
c. To widen the drug therapeutic window
d. To predict plasma drug conc after dosing
What are the benefits of PK modeling?
understand PK-PD correlation & optimize pharmacotherapy
What factors may affect the onset and duration of action?
In PK compartment modeling, the number of compartments depends solely on the _____________ behavior of a drug.
At any time after dosing, is the plasma drug conc same as the drug conc at the site of drug action?
Why do we monitor plasma drug conc?
it's the only practical way
Sets found in the same folder
Modified Release Dosage Forms
Novel Drug Delivery Systems
Other sets by this creator
GI Tract Anatomy and Physiology
Other Quizlet sets
Quiz - Chapter 2-3
Nutrition Chapter 1 Part 1 Lecture Slide Notes