10 terms

Protein Synthesis Inhibitors, Aminoglycosides, Tetracyclines, Chloramphenicol

Protein synthesis inhibitors: buy AT 30 and CCELL at 50
1. Aminoglycosides
2. Tetracyclines
3. Chloramphenicol
4. Clindamycin
5. Erythromycin and Macrolides
6. Linezolid
7. Lincomycin
What are the toxicity of aminoglycosides?
1. Nephrotoxicity
2. Ototoxicity
3. Teratogen
Along with vancomycin
Which drugs have nephrotoxicity and ototoxicity?
1. Aminoglycosides
2. Vancomycin
3. Cisplatin/Carbaplatin
4. Loop diuretics
When on tetracyclines or fluoroquinolones, what must the patient avoid in his/her diet?
1. Milk
2. Antacids,
3. Iron containing preparations
B/c divalent cations inhibits the uptake of tetracyclines (absorption in gut)
What are tetracyclines used to treat? (Mnemonic)
1. Vibrio cholera
2. Acne
3. Chlamydia
4. Ureaplasma urealyticum
5. Mycoplasma
6. Tularemia
7. H. pylori
8. Borrelia burgdorferi (lyme)
9. Rickettsia
What are macrolides used to treat? (Mnemonic)
Atypical Pneumonia: Chlamydia pneumonia, chlamydia psittaci, mycoplasma, legionella
Upper Respiratory Infection: Strep pyogenes, Strep pneumo
STDs: Chlamydia, N. gonorrheae
What is chloramphenicol used for?
1. Meningitis by H. influenza, N. meningiditis, S. pneumonia
What are the toxicities of chloramphenicol
1. Anemia
2. Aplastic anemia
3. Gray baby syndrome in premature infants b/c those infants lack a mature UDP-glucuronyl transferase.
Which drugs are used to treat pseudomonas?
1. Polymyxins
2. Fluoroquinolones
3. Extended spectrum: Ticarcillin, carbenicillin, piperacillin.
4. 3rd/4th generation cephalosporins
5. Aztreonam
Which antibiotic is confined to topical use because of nephrotoxicity?
Neomycin of the aminoglycocides.