1. increase blood flow to injury (VASCULAR RESPONSE) 2. alert products of healing to get to the site (CELLULAR RESPONSE) 3. remove injured tissue to prep for healing
what do vasoactive chemical mediators do?
facilitate the widening/loosening of blood vessels at site of injury. this is the VASCULAR response of inflammation
where can chemical mediators be found? what phases of inflammation are they active in?
plasma and many cells: platelets mast cells basophils neutrophils endothelial cells monocytes macrophages
primary intention vs. secondary intention
wound is basically closed with all areas connecting/healing simultaneously
wound heals from the bottom up.
nodular inflammatory lesions that encase harmful substances. form when injury can't be controlled w/ usual inflammatory/immune mechanisms (ex - foreign bodies, some microorganisms) regulated by macrophages
what do monocytes produce as they mature into macrophages?
fibroblasts and protinases, which break down elastin & other cell components
macrophages adapt into these; capable of engulfing particles much larger than usual.
is there scarring after restoration from acute inflammation?
no, it's minimal. in chronic, however, there is fibrosis, scarring & granuloma formation.
macrophages adapt into these; gather small substances & form a fibrous wall surrounding them
perform specific body functions (neuronal, epithelial, cardiac myocytes, hepatocyes)
3 processes for restoring functioning integrity (the main goal of healing)