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Terms in this set (10)
What is the goal of molecular target therapies?
target tumor specific biomolecules
-exploit differences between normal tissues and cancer cells
What serve as weak points to be exploited in cancer cells?
Molecular-Targeted Therapies have a _______________ spectrum of activity.
Molecular targeted therapies have __________ (high/low) toxicity).
low (side effects tend to be mild compared to conventional therapy_
What chemical family is Imatinib?
tyrosine kinase inhibitor
What is Imatinibs MOA?
acts on BCR-ABL protein fusion of CML. Competes w/ ATP for active site of enzyme.
What is the first line of therapy for Philadelphia Chromosome Positive CML?
What chemical family is Trastuzumab?
What is the pharmacological target of Trastuzumab?
What is Trastuzumabs MOA?
binds HER2 and interferes with dimerization of HER2 required for activation and transmission of pro-growth signals to nucleus via soluble kinases
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