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Inflammation and wound repair lectures 7 and 8 and 9!!!
im tired af, sorry if any dont make sense
Terms in this set (54)
what are the 2 primary functions of lymphatics?
1. drain and sample fluid accumulated in the extracellular matrix
2. delivers antigens collected in periphery to lymph nodes
Lymph flow is increased during inflammation
How does fluid get back into circulation after hydrostatic pressure sends it out, and oncotic pressure doesnt bring it completely back?
-serves as a surveillance role
Where do T cells enter the lymph node cortex?
High endothelial venule (HEV)
what happens to T cells not activated by antigen presented by dendritic cells?
exit the lymph node via cortical sinuses
Lymphangitis and signs
inflammation of lymph vessels
-causes edema and swelling (big legs)
inflammation of the lymph nodes itself
Define reactive hyperplasia
when lymph node is doing what it is supposed to do and enlarges from colonial expansion from immune response
-it itself is not inflamed
will feel the same as the others,
Enlarged lymph node differential order
Normal lymph node enlargement architecture vs abnormal
cortico-medullary architecture. when hyperactive, the cortex expands
the cortico-medullary architecture will disappear with cancer or inflammation of lymph node
What takes action if lympatics are overwhelmed?
Kupffer cells, PIMs, macrophages in spleen, bone marrow, etc...
-filter garbage coming from portal stream
In order, what are the lines of defense?
1. natural barriers
2. sentinel cell populations and lymphatics
Systemic effects of inflammation
Acute phase reaction
-mediated by cytokines TNF a, IL-6, IL-1
Clinical sins of systemic effects of inflammation
elevation of acute phase proteins
Causes of systemic inflammation
All of this starts at a local sight, then systemic effects carry it out (cytokines overflow into bloodstream
Systemic effects of inflammation: Temperature regulation
Thermoregulatory center is located in the hypothalamus
-circumventricular organ system (COVS)
-Prostagllandin (E) production by vascular and perivascular cells
pyrogens (endogenous and exogenous)
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