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PHRD 5056 - Introduction to Radiopharmaceuticals
Terms in this set (41)
What are the two categories of radiopharmaceutical medical usages?
diagnostic and therapeutic
In regards to medical usage, _____ radiopharmaceuticals are used in the determination of a disease state.
In regards to medical usage, _____ radiopharmaceuticals are used in the treatment of a disease.
In regards to medical usage, are diagnostic or therapeutic radiopharmaceuticals the largest group of medications?
In regards to medical usage, which class is associated with gamma emitters?
In regards to medical usage, which class is associated with alpha and beta emitters?
_____ radiopharmaceuticals are based upon the concept of labeling a compound and tracing the compound by detecting the radiation emitted from the radionuclide.
_____ radiopharmaceuticals are based upon the ability of ionizing radiation to destroy cells.
Diagnostic radiopharmaceuticals are based upon the same concept as when these were first discovered and utilized, which is...
labeling and tracing.
What are the two different labeling concepts in relation to diagnostic radiopharmaceuticals?
substitution and foreign labeling
With which labeling concept does the stable atom in a compound replace with a radioactive form of the atom?
What is an example of substitution in regards to labeling concepts?
I-127 sodium iodide (stable) substituted with I-131
WIth which labeling concept is the radioactive atom attached to a compound that does not normally have the atom?
What is an example of foreign labeling in regard to labeling concepts?
Tc99m labeled agents
In regards to diagnostic radiopharmaceuticals, a carrier is the _____ form.7
Which of the following is stable and is therefore a carrier: NaI-127 or NaI-131?
Which of the following is radioactive and is therefore NOT a carrier: NaI-127 or NaI-131?
What are the three important concepts in regards to diagnostic radiopharmaceuticals?
- carrier free
- no pharmacologic effect
- high specific activity
With diagnostic radiopharmaceuticals, both will bind sites in the body, but only one will give the _____ _____.
_____ ______ radiopharmaceuticals are desired.
How would one minimize the carrier form?
have fresh elutions
Specific activity is defined as...
the activity per weight of labeled compound (mCi/mg).
What is part of the radian there is not pharmacologic effects with diagnostic radiopharmaceuticals?
high specific activity
In regards to high specific activity, a _____ amount of activity can be derived from a _____ amount of drug, especially if it is almost carrier-free.
A radiopharmaceutical in FINAL form must remain _____ and _____ _____.
sterile, pyrogen free
It is important to _____ the presence of oxygen when compounding radiopharmaceuticals.
A _____ _____ is crucial for compounding AND dispensing.
What must be performed to ensure the dose calibrator is in proper working condition?
quality control tests
What are the four different quality control/assurance tests used on a dose calibrator?
How often does an accuracy quality assurance test need to be performed?
How often does a precision/constancy quality assurance test need to be performed?
How often does a linearity quality assurance test need to be performed?
How often does a geometry quality assurance test need to be performed?
installation, repair, if moved
Which quality assurance test can measure the TRUE AMOUNT within +/- 5%?
Which quality assurance test makes sure that the setting hasn't changed in the dose calibrator?
Which quality assurance test makes sure the instrument can read over a wide range (within the highs and lows)?
Which quality assurance test measures the position in the well in different volumes and containers?
Does the NRC or DEQ visit in Louisiana?
Does the NRC or DEQ visit in Texas?
In regards to record keeping, _____ _____ records are associated with radiopharmaceuticals, eluate, and instruments.
In regards to record keeping, _____ _____ records are associated with dosimeters.
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