# CIS Neuropharmacology Capstone (Linger)

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The DSAs are meant to give an overall preview. So the DSA is broad and the lecture is more specific
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Terms in this set (74)
CNS:
1.List the 10 major sites of drug action in the CNS.
2.Identify the primary excitatory and inhibitory neurotransmitters in the CNS.
3.Describe the modulatory effects of small molecule neurotransmitters in the CNS.
4.Compare and contrast the pathophysiologic effects of glutamate, GABA, acetylcholine, dopamine, norepinephrine, and serotonin in the CNS; identify clinical indications that may benefit from therapeutic modulation of these neurotransmitter systems.
5.Apply the presented information to clinical scenarios and case studies.

ANS:
1.List the various types and subtypes of cholinergic and adrenergic receptors and their ganglionic nerve terminal and effector organ distribution.
2.Describe the physiological functions and effects of cholinergic and adrenergic stimulation at effector organs (the big table included in the DSA packet under subheading 8).
3.Describe sympathetic and parasympathetic tone.
4.Compare and contrast the sympathetic and parasympathetic effects in response to the administration of cholinergic agonists, cholinergic antagonists, adrenergic agonists, and adrenergic antagonists.
5.Apply the information presented to clinical scenarios and case studies.
Amphetamine shown on left diagram, represented by black circles

-Uses NET transporter or simple diffusion to get into presynaptic neuron

-Once inside, can use VMAT to displace NE from inside vesicles

-Phosphorylation events that lead to reversal of NET, so the NE that's floating around in the neuron because it's been displaced now flows out into the synapse