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Type 1 Hypersensitivity

Terms in this set (27)

Hypersensitivity can be defined as?
Elevated sensitivity to an epitope of an antigen upon 2nd exposure
Immediate hypersensitvities 1,2,&3 all use which cells:
- Memory B cells
- Plasma B cells
- T cells
- Neutrophils
B. Plasma
IgE can bind to to the cell membrane of what cells?
Basophils, mast cells, and eosinophils
What antibody is the "heart of antibody mediated defenses"?
IgG
IgM cannot do which of the following?
- Be a B cell receptor
- Trigger inflammation
- Do aglutination
- Not do aglutination
D.
T/F. The body should be moving towards production of IgG?
True. However, sometimes IgE is produced instead
T/F. Delayed sensitivity (type IV) uses B cellls?
False. Uses T cells
Type 1 immediate is seen as:
- allergens
- diseases
- immune issues
Allergens!
- Such as: peanut, pollen, sea food, iodine, etc.
What are 3 examples of a localized type 1 reaction?
Localized hives, skin rash & hay fever
If someone has a systemic reaction, which part of the body is going to be affected? What is going to be released?
Entire body is affected. There's a huge release of histamine.
- Body wide reaction to a specific allergen (peanuts, bee stings, etc)
What causes the huge release of histamine in a systemic reaction?
Mast cells & basophils
Systemic reaction can cause?
- Anaphylactic shock
- Mild allergens
- Fever
- Hives
A. Anaphylactic shock
Upon 1st exuposure in a type 1 reaction, what will the immune system produce? What is it supposed to produce?
Immune system produces IgE. However, it's supposed to produce IgG
Upon 2nd exposure in a type 1 reaction, what will the antigen act as?
An allergen
When the antigen cross binds on the embedded antibody, what does this cause?
Degranulation & histamine release
Histamine does NOT cause which of the following?
- Vasodilation
- Increase in blood flow
- Sneezing, coughing & diarrhea
- Fever
Fever
How is a type 1 immediate response treated?
Treated with desensitization, through injection or orally
What is the goal of desensitization?
To make the body produce IgG instead of IgE., and to produce Th1 instead of Th2
What does Th1 produce & induce?
Produces interferons & TNF, and induces production of IgG
Why would you want production of Th1 instead of Th2?
Th2 produces IgE, which we don't want. Th1 helps production of IgG, which is what we want
What is the treatment for a systemic response?
Epinephrine
Epinephrine prevents release of?
- Histamine
- Cytokines
- Chemokines
- Neutrophils
Histamine
Epinephrine relaxes what?
Smooth muscle in the respiratory system
Epinephrine causes blood vessels to do what? What does this stablizie?
Causes blood vessels to constrict instead of dilating, which stabilizes blood pressure
Vasodilation causes?
Inflammation
Blood pressure will decrease / increase with a systemic anaphylactic response?
Decrease
Anti-histamines prevent what?
Prevents histamine from binding to body cells, for sneezing & watery eyes
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