What are the clinical manifestations of ALL & AML?
1. Increased infections - (immaturity of white blood cells)
2. Anemia, bruising, epistaxis (nose bleeds) - decreased erythrocyte/platelet production due to leukemic crowding in marrow.
3. Bone pain - leukemic crowding
4. Headaches, visual disturbances, nausea, vomiting, seizures & coma - infiltration into CNS
5. Enlargement/tenderness of organs - infiltration into nodes, spleen, liver
6. Weight loss & fever - unexplained