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Chapter 15- Gene Regulation in Eukaryotes
Terms in this set (20)
Collection of proteins that mediate the binding of RNA polymerase and the initiation of transcription.
general transcription factors
Required for the binding of the RNA pol to the core promoter and its progression to the elongation stage. Are necessary for basal transcription
regulatory transcription factors
Serve to regulate the rate of transcription of target genes. They influence the ability of RNA pol to begin transcription of a particular gene
binding of a regulatory transcription factors that increases the rate of transcription (up-regulation)
binding of a regulatory transcription factors that decreases the rate of transcription (down-regulation)
regulatory transcription factors that respond to steroid hormones
cAMP regulating element-binding protein, binds to cAMP and then binds to the CRE region in DNA which begins transcription.
DNA unpacking involving histone acetylation and DNA demethylation
a tightly packed conformation of chromatin that cannot be transcribed
loosely packed chromatin that can be transcribed into RNA.
an enzyme that loosens the compaction of chromatin by attaching acetyl groups to histone proteins.
proteins that function to remove the acetyl groups from histones
make the chromatin in a more closed conformation
overal decreases the gene expression levels of the cell
The addition of methyl groups to bases of DNA after DNA synthesis; may serve as a long-term control of gene expression.
An enzyme that catalyzes the methylation of DNA.
DNA regions rich in C residues adjacent to G residues. Especially abundant in promoters, these regions are where methylation of cytosine usually occurs.
a gene that is transcribed continually because its product is needed at all times and in all cells
a gene that is highly regulated and is expressed in a particular cell type
Microorganisms require iron
Ferric iron is very insoluble so uptake is difficult
Microorganisms secrete siderophores to aid uptake
Siderophore complexes with ferric ion
Complex is then transported into cell
small single stranded RNA molecules that bind to mRNA and can degrade mRNA or block its translation.
RISC (RNA-induced silencing complex)
A protein complex that is targeted to specific mRNA molecules by base pairing with short regions on the target mRNA, inhibiting translation or degrading the RNA.
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